R1402
Raloxifene hydrochloride
selective estrogen receptor modulator (SERM), solid
别名:
Keoxifene hydrochloride, LY 156758, [6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]methanone hydrochloride
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关于此项目
经验公式（希尔记法）:
C28H27NO4S · HCl
化学文摘社编号:
分子量:
510.04
UNSPSC Code:
51111800
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Form:
solid
产品名称
Raloxifene hydrochloride, solid
form
solid
Quality Segment
color
light yellow
solubility
DMSO: soluble 28 mg/mL, H2O: insoluble
originator
Eli Lilly
SMILES string
Cl[H].Oc1ccc(cc1)-c2sc3cc(O)ccc3c2C(=O)c4ccc(OCCN5CCCCC5)cc4
InChI
1S/C28H27NO4S.ClH/c30-21-8-4-20(5-9-21)28-26(24-13-10-22(31)18-25(24)34-28)27(32)19-6-11-23(12-7-19)33-17-16-29-14-2-1-3-15-29;/h4-13,18,30-31H,1-3,14-17H2;1H
InChI key
BKXVVCILCIUCLG-UHFFFAOYSA-N
Gene Information
human ... ESR2(2100)
Application
Raloxifene hydrochloride has been used:
- as a competitive inhibitors for estrogen receptor α in breast cancer cells
- as an anti-resorptive agents to test its effect on improving bone mineral density (BMD) in six-month-old female ovariectomized rats
- to test effect on viability of esophageal adenocarcinoma cells
Biochem/physiol Actions
Raloxifene is benzothiophene compound and is used in treating postmenopausal osteoporosis It comparatively induces lesser risk in developing thromboembolic events and cataracts compared to tamoxifen. Raloxifene also interacts with estrogen receptors and plasma proteins.
Raloxifene is a selective estrogen receptor modulator (SERM); acts as an anti-estrogen in both breast and uterine tissue while being estrogenic in bone. May have efficacy against estrogen-sensitive cancers.
Features and Benefits
This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
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signalword
Warning
hcodes
Hazard Classifications
Carc. 2 - Repr. 2
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)