R1658
RS-102221 盐酸盐 水合物
≥98% (HPLC)
别名:
4-dione hydrochloride hydrate, 8-[5-(2,4-Dimethoxy-5-(4-trifluoromethylphenylsulphonam ido)phenyl-5-oxopentyl]-1,3,8-triazaspiro[4.5]decane-2
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关于此项目
经验公式(希尔记法):
C27H31F3N4O7S·HCl · xH2O
CAS Number:
分子量:
649.08 (anhydrous basis)
MDL编号:
UNSPSC代码:
12352202
PubChem化学物质编号:
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white
溶解性
DMSO: ≥20 mg/mL
储存温度
2-8°C
SMILES字符串
O.Cl.COc1cc(OC)c(cc1NS(=O)(=O)c2ccc(cc2)C(F)(F)F)C(=O)CCCCN3CCC4(CC3)NC(=O)NC4=O
InChI
1S/C27H31F3N4O7S.ClH.H2O/c1-40-22-16-23(41-2)20(33-42(38,39)18-8-6-17(7-9-18)27(28,29)30)15-19(22)21(35)5-3-4-12-34-13-10-26(11-14-34)24(36)31-25(37)32-26;;/h6-9,15-16,33H,3-5,10-14H2,1-2H3,(H2,31,32,36,37);1H;1H2
InChI key
IGACJTZTAQBWKN-UHFFFAOYSA-N
生化/生理作用
RS-102221 is a selective, high affinity 5-HT2C receptor antagonist.
警示用语:
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Chris M Panzini et al.
Journal of neurochemistry, 143(6), 708-721 (2017-09-28)
In humans a chromosomal hemideletion of the 16p11.2 region results in variable neurodevelopmental deficits including developmental delay, intellectual disability, and features of autism spectrum disorder (ASD). Serotonin is implicated in ASD but its role remains enigmatic. In this study we
Ao Li et al.
CNS neuroscience & therapeutics, 27(8), 941-950 (2021-05-12)
General anesthesia has been widely applied in surgical or nonsurgical medical procedures, but the mechanism behind remains elusive. Because of shared neural circuits of sleep and anesthesia, whether serotonergic system, which is highly implicated in modulation of sleep and wakefulness
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