R2153
RU 26752
≥98% (HPLC), solid
别名:
17α-Hydroxy-3-oxo-7α-propylpregn-4-ene-21-carboxylic acid γ-lactone
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关于此项目
经验公式（希尔记法）:
C25H36O3
化学文摘社编号:
分子量:
384.55
UNSPSC Code:
51111800
PubChem Substance ID:
MDL number:
Quality Level
assay
≥98% (HPLC)
form
solid
solubility
DMSO: soluble 20 mg/mL at 60 °C (warming up for 20 minutes)
storage temp.
−20°C
SMILES string
[H][C@]12CC[C@@]3(C)[C@@]([H])(CC[C@@]34CCC(=O)O4)[C@]1([H])[C@H](CCC)CC5=CC(=O)CC[C@]25C
InChI
1S/C25H36O3/c1-4-5-16-14-17-15-18(26)6-10-23(17,2)19-7-11-24(3)20(22(16)19)8-12-25(24)13-9-21(27)28-25/h15-16,19-20,22H,4-14H2,1-3H3/t16-,19+,20+,22-,23+,24+,25-/m1/s1
InChI key
MOFIIHQCTIJVBB-JEHIOXJOSA-N
Biochem/physiol Actions
Mineralocorticoid receptor antagonist.
RU 26752 is a mineralocorticoid receptor antagonist.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Chronic 4
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
M Mirshahi et al.
Biochemical and biophysical research communications, 270(3), 811-815 (2000-04-25)
PCR analysis and Western blotting revealed the expression of the mineralocorticoid receptor (MCR) and the epithelial sodium channel (ENaC) genes at the level of RNA, DNA, and protein in several leukemic cell lines, fibroblasts from human cornea, and epithelial cells
Sanjay Rajagopalan et al.
The Medical clinics of North America, 87(2), 441-457 (2003-04-16)
Based upon the results of the RALES trial and accumulating evidence about the role of aldosterone and aldosterone receptor antagonism in various disease states, the authors anticipate that aldosterone receptor antagonists will become standard therapy, along with ACE inhibitors and
Saaeha Rauz et al.
Investigative ophthalmology & visual science, 44(4), 1643-1651 (2003-03-27)
In peripheral sodium-transporting tissues, the serum- and glucocorticoid-regulated kinase (SGK) isoform-1 is an early corticosteroid target gene in the activation of epithelial sodium channels (ENaCs). Sodium transport across the human ocular nonpigmented and pigmented ciliary epithelial bilayer (NPE-PE) is essential
A Souque et al.
The Journal of steroid biochemistry and molecular biology, 57(5-6), 315-321 (1996-03-01)
To investigate the role of sulfhydryl groups in the interaction of agonists and antagonists with the human mineralocorticoid receptor (hMR) the effect of methyl methanethiosulfonate (MMTS) on free and liganded-hMR was examined. hMR was expressed in insect cells (Sf9) using
G Lazar et al.
Biochimica et biophysica acta, 1033(1), 41-48 (1990-01-29)
Cardiac cytosol from adrenalectomized rats was radiolabelled with 10 nM tritiated RU 26752, R 5020 or aldosterone, to saturate the mineralocorticoid receptor (MCR) in the presence of 1 microM RU 38486 to block the glucocorticoid and progestin receptors. Free steroids
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