R2533
RS-127445 hydrochloride
≥98% (HPLC), powder
别名:
2-Amino-4-(4-fluoronaphth-1-yl)-6-isopropylpyrimidine hydrochloride
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关于此项目
经验公式（希尔记法）:
C17H16FN3 · HCl
化学文摘社编号:
分子量:
317.79
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
方案
≥98% (HPLC)
表单
powder
储存条件
desiccated
颜色
white to tan
溶解性
DMSO: ≥20 mg/mL
创始人
Roche
储存温度
2-8°C
SMILES字符串
Cl.CC(C)c1cc(nc(N)n1)-c2ccc(F)c3ccccc23
InChI
1S/C17H16FN3.ClH/c1-10(2)15-9-16(21-17(19)20-15)13-7-8-14(18)12-6-4-3-5-11(12)13;/h3-10H,1-2H3,(H2,19,20,21);1H
InChI key
MKJPYBJBPRFMHL-UHFFFAOYSA-N
生化/生理作用
RS-127445 is a selective; high affinity; orally bioavailable serotonin 5-HT2B receptor antagonist.
RS-127445 is a selective; high affinity; orally bioavailable serotonin 5-HT2B receptor antagonist. RS-127445 was found to have nanomolar affinity for the 5-HT2B receptor (pKi=9.5) and 1,000 fold selectivity for this receptor as compared to numerous other receptor and ion channel binding sites.
特点和优势
This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
警示用语：
Danger
危险分类
Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Maximilian Breuer et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 39(4), 498-512 (2024-03-13)
Mutations in the Chromodomain helicase DNA-binding protein 7 - coding gene (CHD7) cause CHARGE syndrome (CS). Although craniofacial and skeletal abnormalities are major features of CS patients, the role of CHD7 in bone and cartilage development remain largely unexplored. Here
Yu-Chan Chang et al.
Cell communication and signaling : CCS, 22(1), 266-266 (2024-05-14)
Glioblastoma (GBM) is a type of brain cancer categorized as a high-grade glioma. GBM is characterized by limited treatment options, low patient survival rates, and abnormal serotonin metabolism. Previous studies have investigated the tumor suppressor function of aldolase C (ALDOC)
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