Merck
CN

R2625

Sigma-Aldrich

视黄酸

≥98% (HPLC), powder

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别名:
ATRA, 全反式维甲酸, 维生素A酸, 维甲酸
经验公式(希尔记法):
C20H28O2
CAS号:
分子量:
300.44
Beilstein:
2057223
EC 号:
MDL编号:
PubChem化学物质编号:
NACRES:
NA.77

生物来源

synthetic (organic)

质量水平

检测方案

≥98% (HPLC)

形式

powder

technique(s)

cell culture | mammalian: suitable

颜色

yellow

mp

180-181 °C (lit.)

溶解性

chloroform: 50 mg/mL

储存温度

−20°C

SMILES string

CC1=C(\C=C\C(C)=C\C=C\C(C)=C\C(O)=O)C(C)(C)CCC1

InChI

1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+

InChI key

SHGAZHPCJJPHSC-YCNIQYBTSA-N

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相关类别

应用

  • 视黄酸(RA)已用于胚胎干细胞至运动神经元的分化。
  • 它已用于非洲爪蟾外胚层至胰腺的分化。
  • 它还用于研究由RARα (视黄酸受体α)引起的表观遗传学调控。
  • 它已用于研究原初精原细胞向精母细胞转化的RA信号转导。

生化/生理作用

全−反式−视黄酸(ATRA)是视黄酸受体(RAR)和视黄醇类 X 受体(RXR)的配体。所结合的RAR和RXR可作为调节正常细胞和恶性细胞的生长和分化的转录因子。细胞色素P450(CYP)可催化ATRA的4-羟基化。视黄酸可使胚胎干细胞成为神经元。

特点和优势

该化合物在受体分类和信号转导手册中 核受体(非甾体化合物) 页面中进行了详细介绍。欲浏览其他手册页面,请 点击这里

警示用语:

Danger

危险分类

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Repr. 1B - Skin Irrit. 2

储存分类代码

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves


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  1. What are the I.U. for Product R2625, Retinoic acid?

    This product is not characterized by the activity in I.U. The purity specification, however, is not less than 98% by HPLC.

  2. How should I store the solutions of Product R2625, Retinoic acid?

    Retinoic acid is sensitive to air and light. Solutions should be stored under argon gas, preferably as aliquots at -70°C.

  3. What is the shelf life of Product R2625, Retinoic acid?

    R2625 has a shelf-life of two years. Shelf-life dates are found on Specification sheet on our website.

  4. Why is Product R2625, Retinoic acid not shipped on dry ice?

    Dry ice is not necessary for shipment, since Product No. R2625 is stable to ship at ambient temperature for up to two weeks. Once received, it should be stored at -20°C.

  5. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  6. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  7. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  8. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

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