R2905
Anti-RAE1 (C-terminal) 兔抗
~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution
别名:
Anti-MRNP41, Anti-RNA export 1, Anti-mRNA-binding protein 41 kDa
生物来源
rabbit
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen 43 kDa
种属反应性
human, mouse, rat
浓度
~1.0 mg/mL
技术
western blot: 1-2 μg/mL using 3T3 and RIN5 cell lysates
western blot: 2-4 μg/mL using HEK-293T cell lysate
UniProt登记号
运输
dry ice
储存温度
−20°C
基因信息
human ... RAE1(8480)
mouse ... Rae1(66679)
rat ... Rae1(362281)
一般描述
RAE1 (mRNA export factor 1) is a nucleic acid-binding protein. It is also called as Gle2 (RNA export factor) or mrnp41 (mRNA binding protein mrnp 41). It is located on human chromosome 20q13.
免疫原
synthetic peptide corresponding to amino acids 349-366 of human RAE1, conjugated to KLH via an N-terminal added cysteine residue. The corresponding sequence is identical in rat and mouse.
应用
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)
Western Blotting (1 paper)
生化/生理作用
Suppression of RAE1 (mRNA export factor 1) affects the mitotic spindle assembly. It involves in mRNA export as mRNP-interacting protein. In mouse, Rae1 is necessary for early embryogenesis.
外形
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
12 - Non Combustible Liquids
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
新产品
此项目有
A Rae1-containing ribonucleoprotein complex is required for mitotic spindle assembly
Blower MD, et al.
Cell, 121(2), 223-234 (2005)
Early aging-associated phenotypes in Bub3/Rae1 haploinsufficient mice
Baker DJ, et al.
The Journal of Cell Biology, 172(4), 529-540 (2006)
The evolution of imprinting: chromosomal mapping of orthologues of mammalian imprinted domains in monotreme and marsupial mammals
Edwards CA, et al.
BMC Evolutionary Biology, 7:157 (2007)
Vesiculoviral matrix (M) protein occupies nucleic acid binding site at nucleoporin pair (Rae1 ? Nup98)
Quan B, et al.
Proceedings of the National Academy of Sciences of the USA, 111(25), 9127-9132 (2014)
RAE1 is a shuttling mRNA export factor that binds to a GLEBS-like NUP98 motif at the nuclear pore complex through multiple domains
Pritchard CE, et al.
The Journal of Cell Biology, 145(2), 237-254 (1999)
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