R2905
Anti-RAE1 (C-terminal) 兔抗
~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution
别名:
Anti-MRNP41, Anti-RNA export 1, Anti-mRNA-binding protein 41 kDa
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 43 kDa
species reactivity
human, mouse, rat
concentration
~1.0 mg/mL
technique(s)
western blot: 1-2 μg/mL using 3T3 and RIN5 cell lysates, western blot: 2-4 μg/mL using HEK-293T cell lysate
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
Gene Information
human ... RAE1(8480)
mouse ... Rae1(66679)
rat ... Rae1(362281)
General description
RAE1 (mRNA export factor 1) is a nucleic acid-binding protein. It is also called as Gle2 (RNA export factor) or mrnp41 (mRNA binding protein mrnp 41). It is located on human chromosome 20q13.
Immunogen
synthetic peptide corresponding to amino acids 349-366 of human RAE1, conjugated to KLH via an N-terminal added cysteine residue. The corresponding sequence is identical in rat and mouse.
Application
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)
Western Blotting (1 paper)
Biochem/physiol Actions
Suppression of RAE1 (mRNA export factor 1) affects the mitotic spindle assembly. It involves in mRNA export as mRNP-interacting protein. In mouse, Rae1 is necessary for early embryogenesis.
Physical form
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
12 - Non Combustible Liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
新产品
此项目有
A Rae1-containing ribonucleoprotein complex is required for mitotic spindle assembly
Blower MD, et al.
Cell, 121(2), 223-234 (2005)
Vesiculoviral matrix (M) protein occupies nucleic acid binding site at nucleoporin pair (Rae1 ? Nup98)
Quan B, et al.
Proceedings of the National Academy of Sciences of the USA, 111(25), 9127-9132 (2014)
The evolution of imprinting: chromosomal mapping of orthologues of mammalian imprinted domains in monotreme and marsupial mammals
Edwards CA, et al.
BMC Evolutionary Biology, 7:157 (2007)
Early aging-associated phenotypes in Bub3/Rae1 haploinsufficient mice
Baker DJ, et al.
The Journal of Cell Biology, 172(4), 529-540 (2006)
RAE1 is a shuttling mRNA export factor that binds to a GLEBS-like NUP98 motif at the nuclear pore complex through multiple domains
Pritchard CE, et al.
The Journal of Cell Biology, 145(2), 237-254 (1999)
相关内容
Instructions
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