R3151
Monoclonal Anti-Rhodopsin Kinase 1A antibody produced in mouse
clone G8, purified immunoglobulin, buffered aqueous solution
别名:
Anti-GRK1a
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关于此项目
Conjugate:
unconjugated
Clone:
G8, monoclonal
Application:
IF, IP, WB
Citations:
2
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
G8, monoclonal
form
buffered aqueous solution
species reactivity
rat, bovine, chicken, human, mouse
technique(s)
immunoprecipitation (IP): suitable, indirect immunofluorescence: suitable, western blot: suitable
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... GRK1(6011)
mouse ... Grk1(24013)
rat ... Grk1(81760)
General description
GRK1 (rhodopsin kinase) is an enzyme that belongs to serine/threonine protein kinase family and expresses mainly in rod and cone photoreceptors. It has a crucial role in phosphorylation of photoactivated rhodopsin and hence starting steps in its deactivation. Monoclonal anti-rhodopsin kinase 1a antibody can be used in immunoprecipitation. Mouse anti-rhodopsin kinase 1a antibody reacts specifically with an epitope present in the C-terminal region of mouse, bovine, rat, chicken and human GRK1a. The product has shown no cross-reactivity with other G protein coupled kinases together with GRK1b.
Rhodopsin Kinase 1A encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates rhodopsin and initiates its deactivation.
Immunogen
derived from human GRK1
Application
Monoclonal anti-rhodopsin kinase 1a antibody can be used in indirect immunofluorescence and western blotting.
Physical form
Supplied in phosphate buffered saline containing 0.05% sodium azide.
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
X Zhao et al.
FEBS letters, 454(1-2), 115-121 (1999-07-21)
The G protein-coupled receptor kinases (GRKs) are important enzymes in the desensitization of activated G protein-coupled receptors (GPCR). Seven members of the GRK family have been identified to date. Among these enzymes, GRK1 is involved in phototransduction and is the
X Zhao et al.
The Journal of biological chemistry, 273(9), 5124-5131 (1998-03-28)
The G protein-coupled receptor kinases (GRKs) are critical enzymes in the desensitization of activated G protein-coupled receptors. Six members of the GRK family have been identified to date. Among these enzymes, GRK1 (rhodopsin kinase) is involved in phototransduction and is
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