R3151
Monoclonal Anti-Rhodopsin Kinase 1A antibody produced in mouse
clone G8, purified immunoglobulin, buffered aqueous solution
别名:
Anti-GRK1a
生物来源
mouse
质量水平
偶联物
unconjugated
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
G8, monoclonal
表单
buffered aqueous solution
种属反应性
rat, bovine, chicken, human, mouse
技术
immunoprecipitation (IP): suitable
indirect immunofluorescence: suitable
western blot: suitable
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... GRK1(6011)
mouse ... Grk1(24013)
rat ... Grk1(81760)
一般描述
GRK1 (rhodopsin kinase) is an enzyme that belongs to serine/threonine protein kinase family and expresses mainly in rod and cone photoreceptors. It has a crucial role in phosphorylation of photoactivated rhodopsin and hence starting steps in its deactivation. Monoclonal anti-rhodopsin kinase 1a antibody can be used in immunoprecipitation. Mouse anti-rhodopsin kinase 1a antibody reacts specifically with an epitope present in the C-terminal region of mouse, bovine, rat, chicken and human GRK1a. The product has shown no cross-reactivity with other G protein coupled kinases together with GRK1b.
Rhodopsin Kinase 1A encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates rhodopsin and initiates its deactivation.
免疫原
derived from human GRK1
应用
Monoclonal anti-rhodopsin kinase 1a antibody can be used in indirect immunofluorescence and western blotting.
外形
Supplied in phosphate buffered saline containing 0.05% sodium azide.
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储存分类代码
10 - Combustible liquids
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
X Zhao et al.
FEBS letters, 454(1-2), 115-121 (1999-07-21)
The G protein-coupled receptor kinases (GRKs) are important enzymes in the desensitization of activated G protein-coupled receptors (GPCR). Seven members of the GRK family have been identified to date. Among these enzymes, GRK1 is involved in phototransduction and is the
X Zhao et al.
The Journal of biological chemistry, 273(9), 5124-5131 (1998-03-28)
The G protein-coupled receptor kinases (GRKs) are critical enzymes in the desensitization of activated G protein-coupled receptors. Six members of the GRK family have been identified to date. Among these enzymes, GRK1 (rhodopsin kinase) is involved in phototransduction and is
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