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Merck
CN

R3250

视黄醇乙酸酯

synthetic, matrix dispersion, 475,000-650,000 USP units/g

别名:

维生素 A 醋酸酯, 醋酸维生素 A

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关于此项目

经验公式(希尔记法):
C22H32O2
化学文摘社编号:
分子量:
328.49
NACRES:
NA.79
PubChem Substance ID:
eCl@ss:
34058009
UNSPSC Code:
12352205
EC Number:
204-844-2
MDL number:
Beilstein/REAXYS Number:
1915439
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产品名称

视黄醇乙酸酯, synthetic, matrix dispersion, 475,000-650,000 USP units/g

InChI key

QGNJRVVDBSJHIZ-QHLGVNSISA-N

InChI

1S/C22H32O2/c1-17(9-7-10-18(2)14-16-24-20(4)23)12-13-21-19(3)11-8-15-22(21,5)6/h7,9-10,12-14H,8,11,15-16H2,1-6H3/b10-7+,13-12+,17-9+,18-14+

SMILES string

CC1=C(/C=C/C(C)=C/C=C/C(C)=C/COC(C)=O)C(C)(C)CCC1

biological source

synthetic

form

matrix dispersion

specific activity

475,000-650,000 USP units/g

color

yellow

mp

57-58 °C

storage temp.

−20°C

Quality Level

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Analysis Note

Activity based on HPLC comparison to USP standard.

Application

Retinyl acetate has been used:
  • a control diet to study its effect at different developmental periods in fish larvae
  • to study its inhibitory effects on Mycobacterium avium subspecies paratuberculosis (MAP) strains
  • as an internal standard in high performance liquid chromatography (HPLC) to quantify vitamin A in fortified milk

Biochem/physiol Actions

Retinyl esters provide pools of vitamin A that are converted into retinol and other retinoids as required. Retinyl acetate is used in a wide range of biological applications. It acts as a chemopreventive agent. Retinyl acetate also has antineoplastic property.

General description

Retinal, retinol and retinoic acid are the aldehyde, alcohol and acid forms of vitamin A. The retinoids exist as many geometric isomers due to the unsaturated bonds in the aliphatic chain. Retinoids also exist as retinyl esters such as retinyl propionate, retinyl acetate and retinyl palmitate.

Physical form

Dispersion in cornstarch-gelatin matrix. Oil dispersible

pictograms

Health hazard

signalword

Danger

Hazard Classifications

Aquatic Chronic 4 - Repr. 1B

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type ABEK (EN14387) respirator filter


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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访问文档库

Vitamins A & D inhibit the growth of mycobacteria in radiometric culture
Greenstein RJ, et al.
PLoS ONE, 7(1), e29631-e29631 (2012)
A survey of vitamin A and D contents of fortified fluid milk in Ontario
Faulkner H, et al.
Journal of Dairy Science, 83(6), 1210-1216 (2000)
Cancer chemopreventive activity mediated by deguelin, a naturally occurring rotenoid
Udeani GO, et al.
Cancer Research, 57(16), 3424-3428 (1997)
Effect of combined selenium and retinyl acetate treatment on mammary carcinogenesis
Thompson HJ, et al.
Cancer Research, 41(4), 1413-1416 (1981)
Intake of high levels of vitamin A and polyunsaturated fatty acids during different developmental periods modifies the expression of morphogenesis genes in European sea bass (Dicentrarchus labrax)
Villeneuve LAN, et al.
The British Journal of Nutrition, 95(4), 677-687 (2006)

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