R3405
RP-107
≥98% (HPLC), solid
别名:
7-n-Butyl-6-(4-hydroxyphenyl)[5H]-pyrrolo[2,3-b]pyrazine
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关于此项目
经验公式（希尔记法）:
C16H17N3O
化学文摘社编号:
分子量:
267.33
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
InChI
1S/C16H17N3O/c1-2-3-4-13-14(11-5-7-12(20)8-6-11)19-16-15(13)17-9-10-18-16/h5-10,20H,2-4H2,1H3,(H,18,19)
SMILES string
CCCCc1c([nH]c2nccnc12)-c3ccc(O)cc3
InChI key
PRIGRJPRGZCFAS-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
solid
storage condition
desiccated
solubility
DMSO: >10 mg/mL, H2O: insoluble
storage temp.
2-8°C
Biochem/physiol Actions
RP107 is an activator of cystic fibrosis transmembrane conductance regulator (CFTR) channel.
RP107 is an activator of cystic fibrosis transmembrane conductance regulator (CFTR) channel. RP107 stimulates wild-type CFTR and mutated CFTR with submicromolar affinity by a cAMP-independent mechanism. EC50 = 89 nM at activating CFTR-dependent C-secretion, an effect inhibited by CFTR(inh)-172 and glibenclaminde. RP107 constitutes a new example of a scaffold structure for the selective activation of CFTR receptors.
Features and Benefits
This compound is featured on the Chloride Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
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