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Merck
CN

R4155

Anti-hnRNP-E1/E2 (N-terminal) antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution

别名:

Anti-HNRPE1/HNRPE2, Anti-Heterogeneous nuclear ribonucleoprotein E1/E2, Anti-PCBP1/PCBP2, Anti-poly(rC) binding protein 1 /protein 2

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NACRES:
NA.41
UNSPSC Code:
12352203

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产品名称

Anti-hnRNP-E1/E2 (N-terminal) antibody produced in rabbit, ~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~37 kDa

species reactivity

human, rat, mouse

packaging

antibody small pack of 25 μL

concentration

~1.0 mg/mL

technique(s)

immunoprecipitation (IP): 5-10 μg using K562 cell extract
western blot: 0.5-1 μg/mL using K562 cell extract

UniProt accession no.

Q15365

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... PCBP1(5093)
mouse ... Pcbp1(23983)
rat ... Pcbp1(500242)

Application

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)

Biochem/physiol Actions

hnRNP-E1/E2 (heterogeneous nuclear ribonucleoproteins) participates in the development and progression of tumor. It is involved in several transcriptional and posttranscriptional events like mRNA transcription regulation, transportation, splicing, translation, and stabilization. It plays critical roles in cancer apoptosis, metastasis, invasion and malignant transformation. It may also participates in epithelial-mesenchymal transition (EMT).

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

hnRNP-E1/E2 (heterogeneous nuclear ribonucleoproteins) belongs to hnRNP (heterogeneous ribonucleoprotein) family. It is also known as poly-C binding proteins (PCBP) 1 and 2. It is located on chromosome 2p13. PCBP1 gene has no intron and codes for a 356 amino acid poly (rC) binding protein 1, that is of 35kDa. It has three K-Homology (KH) domains and two nuclear localization signals.

Physical form

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

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存储类别

10 - Combustible liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

法规信息

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分析证书(COA)

Lot/Batch Number
068K4768

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Downregulated Poly-C binding protein-1 is a novel predictor associated with poor prognosis in Acute Myeloid Leukemia
Zhou M and Tong X
Diagnostic Pathology, 10:147 (2015)
Expression of poly(C)-binding protein 1 (PCBP1) in NSCLC as a negative regulator of EMT and its clinical value
Liu Y, et al.
International Journal of Clinical and Experimental Pathology, 8(6), 7165-7172 (2015)
Molecular determinants of the axonal mRNA transcriptome
Gomes C, et al.
Developmental neurobiology, 74(3), 218-232 (2014)
Emerging novel functions of the oxygen-sensing prolyl hydroxylase domain enzymes
Wong BW, et al.
Trends in Biochemical Sciences, 38(1), 3-11 (2013)
The PCBP1 gene encoding poly(rC) binding protein I is recurrently mutated in Burkitt lymphoma
Wagener R, et al.
Genes Chromosomes Cancer, 54(9), 555-564 (2015)
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Data Sheet - R4155

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