R4903
Anti-hnRNP-L antibody, Mouse monoclonal
clone 4D11, purified from hybridoma cell culture
别名:
Anti-Heterogeneous Nuclear Ribonucleoprotein-L
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关于此项目
Conjugate:
unconjugated
Clone:
4D11, monoclonal
Application:
ARR, ELISA (i), ICC, IP, WB
Citations:
16
biological source
mouse
Quality Segment
conjugate
unconjugated
antibody form
purified from hybridoma cell culture
antibody product type
primary antibodies
clone
4D11, monoclonal
form
buffered aqueous solution
mol wt
antigen ~68 kDa
species reactivity
bovine, newt, chicken, human, monkey, mouse
technique(s)
immunocytochemistry: suitable, immunoprecipitation (IP): suitable, indirect ELISA: suitable, microarray: suitable, western blot: 0.25-0.5 μg/mL using total cell extract of MDBK cells
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... HNRNPL(3191)
mouse ... Hnrnpl(15388)
General description
Monoclonal Anti-hnRNP-L (mouse IgG1 isotype) is derived from the 4D11 hybridoma produced by the fusion of mouse myeloma cells (SP2/0 cells) and splenocytes from BALA/c mice immunized with hnRNP proteins and purified by affinity chromatography on ssDNA-agarose. RNA polymerase II transcripts in the nucleus are in complex with several proteins called heterogeneous nuclear ribonucleoproteins (hnRNPs). hnRNPs consist of protein groups named A to U and many of these protein groups consist of more than one isoform. Group L and M are one of the most abundant groups of proteins.
Immunogen
hnRNP proteins.
Application
Anti-hnRNP-L antibody has been used in
- immunoblotting
- enzyme linked immunosorbent assay (ELISA)
- immunoprecipitation
- immunocytochemistry
- western blotting
Biochem/physiol Actions
Heterogeneous nuclear ribonucleoproteins-L (hnRNP-L) is involved in splicing regulations, internal translation initiation of hepatitis C virus (HCV), stability of the human vascular endothelial growth factor (VEGF) mRNA under hypoxic growth conditions, and intron independent mRNA export.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, and 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)