Merck
CN

R5010

Sigma-Aldrich

白藜芦醇

≥99% (HPLC)

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别名:
3,4′,5-三羟基-反式-二苯乙烯, 5-[(1E)-2-(4-羟基苯基)乙烯基]-1,3-苯二酚
经验公式(希尔记法):
C14H12O3
CAS号:
分子量:
228.24
MDL编号:
PubChem化学物质编号:
NACRES:
NA.25

生物来源

plant root (bushy knotweed)

质量水平

检测方案

≥99% (HPLC)

形式

powder

溶解性

acetone: 50 mg/mL, clear, faintly yellow

应用

metabolomics
vitamins, nutraceuticals, and natural products

储存温度

−20°C

SMILES字符串

Oc1ccc(cc1)\C=C\c2cc(O)cc(O)c2

InChI

1S/C14H12O3/c15-12-5-3-10(4-6-12)1-2-11-7-13(16)9-14(17)8-11/h1-9,15-17H/b2-1+

InChI key

LUKBXSAWLPMMSZ-OWOJBTEDSA-N

基因信息

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应用

白藜芦醇已用于:
  • 包封实验
  • 研究其对Ca2+/钙调蛋白依赖性蛋白激酶II的糖尿病诱导激活介导的视网膜神经元细胞死亡的神经保护作用
  • 用作体内荧光法评估葡萄叶stilbene含量的标准品

COX-1 选择性抑制剂。

生化/生理作用

白藜芦醇是一种在葡萄皮和其他植物中发现的酚类植物抗毒素。这种成分具有胞内抗氧化活性,可激活烟酰胺腺嘌呤二核苷酸(NAD+)依赖性组蛋白脱乙酰基酶1 (SIRT1),参与线粒体生物发生、增强过氧化物酶体增殖物激活受体γ共激活因子-1a (PGC-1a)和FOXO(叉头框)活性。白藜芦醇的抗糖尿病、神经保护和抗脂肪形成作用可能是通过SIRT1的激活而介导的。白藜芦醇对单纯疱疹病毒-1 (HSV1)和HSV2具有抗病毒作用。此外,它还具有抗肿瘤和植物雌激素生物活性。目前确知白藜芦醇可通过介导几种生理事件,延长许多物种的寿命。

制备说明

可溶于乙醇、DMSO和丙酮。 仅有极少量的可溶于水(3 mg/100 mL)。

象形图

Exclamation mark

警示用语:

Warning

危险声明

危险分类

Eye Irrit. 2

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

392.0 °F - closed cup - (External MSDS)

闪点(°C)

> 200.0 °C - closed cup - (External MSDS)

个人防护装备

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


分析证书(COA)

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示例

T1503
货号
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25G
包装规格/数量

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705578-5MG-PW

PL860-CGA/SHF-1EA

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1000309185

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索取COA

  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I dissolve Resveratrol, Product R5010?

    We test the solubility in ethanol at a concentration of 50 mg/mL.  It is also soluble at 16 mg/mL in DMSO (with sonication). It is practically insoluble in water.

  4. How do I store Resveratrol, Product R5010, once in solution?

    A 5 mM solution of R5010 in ethanol has been found to be stable for 12 weeks when stored at 2-8°C and protected from light.Given a molecular weight of 228.24, a 5 mM solution is approximately 1.1 mg/mL.Reference: D.M. Goldberg, et al., J. Chrom. A, 708, 89-98 (1995). 

  5. In what applications do researchers use Resveratrol, Product R5010?

    There are numerous applications for Resveratrol.  Several references indicate that it is used as a COX-1 inhibitor and a tumor repressor.

  6. Can Resveratrol, Product R5010, be used as a treatment for human patients?

    No. Unfortunately, none of our catalog items are suitable for pharmaceutical applications.  To inquire further on our ability to provide USP material please email our SAFC Pharma group at SAFCglobal@sial.com.

  7. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  8. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  9. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Resveratrol inhibits neuronal apoptosis and elevated Ca2+/calmodulin-dependent protein kinase II activity in diabetic mouse retina
Kim YH, et al.
Diabetes, 59(7), 1825-1835 (2010)
Therapeutic potential of resveratrol: the in vivo evidence
Baur JA and Sinclair DA
Nature Reviews Drug Discovery, 5(6), 493-493 (2006)
Fast and local assessment of stilbene content in grapevine leaf by in vivo fluorometry
Poutaraud A, et al.
Journal of Agricultural and Food Chemistry, 55(13), 4913-4920 (2007)
Halloysite clay nanotubes for resveratrol delivery to cancer cells
Vergaro V, et al.
Macromolecular Bioscience, 12(9), 1265-1271 (2012)
Resveratrol improves health and survival of mice on a high-calorie diet
Baur JA, et al.
Nature, 444(7117), 337-337 (2006)

商品

Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.

抗氧化剂可保护生物系统免受含氧自由基和氧化还原过渡金属离子(如铁、铜和镉)引起的氧化损伤。

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