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R5143

芸香素 水合物

≥94% (HPLC), powder

别名:

Quercetin-3-rutinoside 水合物, Vitamin P 水合物

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关于此项目

经验公式（希尔记法）:
C27H30O16 · xH2O
化学文摘社编号:
207671-50-9
分子量:
610.52 (anhydrous basis)
UNSPSC Code:
12352201
NACRES:
NA.25
PubChem Substance ID:
24899379
EC Number:
205-814-1
Beilstein/REAXYS Number:
75455
MDL number:
MFCD01319140
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Quality Level

200

assay

≥94% (HPLC)

form

powder

color

yellow to green

mp

195 °C (dec.) (lit.)

solubility

pyridine: 50 mg/mL, DMSO: soluble, aqueous base: soluble

application(s)

metabolomics
vitamins, nutraceuticals, and natural products

SMILES string

[H]O[H].O[C@H]1[C@H](OC[C@H]([C@H]2O)O[C@@H](OC(C3=O)=C(C4=CC=C(O)C(O)=C4)OC5=C3C(O)=CC(O)=C5)[C@H](O)[C@H]2O)O[C@H]([C@@H]([C@H]1O)O)C

InChI

1S/C27H30O16.H2O/c1-8-17(32)20(35)22(37)26(40-8)39-7-15-18(33)21(36)23(38)27(42-15)43-25-19(34)16-13(31)5-10(28)6-14(16)41-24(25)9-2-3-11(29)12(30)4-9;/h2-6,8,15,17-18,20-23,26-33,35-38H,7H2,1H3;1H2/t8-,15+,17-,18+,20+,21-,22+,23+,26+,27-;/m0./s1

InChI key

PGHSKTKIQIBATG-ZAAWVBGYSA-N

General description

Rutin hydrate has radioprotective and antiplatelet activity. Rutin reduces hepatic and blood cholesterol levels.

Application

Rutin hydrate has been used:
  • as an inhibitory compound against Skeletonema costatum
  • to analyze the phenolic component and antioxidant activity of nettle
  • to assess the flavonoid content in Propolis

Biochem/physiol Actions

A polyphenolic flavonoid that acts as an antioxidant and NO scavenger. It can attenuate peroxide production in glial cells by acting as a free radical scavenger and protect renal cells from oxidative injury. Inclusion of rutin in the diet of rats significantly reduced the appearance of single-strand breaks in nuclear DNA caused by hepatocarcinogens aflatoxin B1 and N-nitrosodiumethylamine. This protection from DNA damage was found to be due to a reduction in the induction of repair enzymes polymerase, DNA polymerase β and DNA ligase. Since DNA damage and inefficient repair are thought to initiate the process of carcinogenesis, effects of rutin on these functions suggests a protective role of this flavonoid against carcinogenesis induced by chemical carcinogens.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

法规信息

涉药品监管产品

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCN1808
BCCL7880
BCCJ3238
BCCH1908
BCCG8099

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实验方案

HPLC Analysis of Polyphenols in Nero d'Avola Red Wine on Discovery® HS C18 (UV 280 nm)

HPLC Analysis of Polyphenols in Nero d'Avola Red Wine on Discovery® HS C18 (UV 280 nm)

Phenolic compounds analysis of root, stalk, and leaves of nettle
Otles S and Yalcin B
TheScientificWorldJournal, 2012 (2012)
In-vitro evaluation of rutin and rutin hydrate as potential radiation countermeasure agents
Ojha H, et al.
International Journal of Radiation Research, 14(1), 9-9 (2016)
E A Mazzio et al.
Planta medica, 64(7), 603-606 (1998-11-12)
Glial cell monoamine oxidase (MAO) activity has been implicated as a contributor to oxidative neuronal damage associated with various neurodegenerative diseases. The attenuation of MAO activity may provide protection against oxidative neurodegeneration. In this investigation, the presence of MAO-B in
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全球贸易项目编号

货号GTIN
R5143-100G04061835327232
R5143-500G04061832410944
R5143-50G04061835327249