R6267
RANTES human
≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
别名:
Regulated on Activation, Normal T-cell Expressed and Secreted
产品名称
RANTES human, ≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
biological source
human
recombinant
expressed in E. coli
assay
≥97% (SDS-PAGE)
form
lyophilized powder
potency
1-5 ng/mL EC50
mol wt
7.8-8.7 kDa
packaging
pkg of 10 μg
storage condition
avoid repeated freeze/thaw cycles
technique(s)
cell culture | mammalian: suitable
impurities
endotoxin, tested
UniProt accession no.
storage temp.
−20°C
Quality Level
Gene Information
human ... CCL5(6352)
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Analysis Note
The biological activity is tested in culture using Baf/3 cells. Chemotaxis: EC50: 1-5 ng/mL
Biochem/physiol Actions
Regulated on activation, normal T cell expressed and secreted (RANTES) is a chemoattractant towards monocytes, dendritic cells (DCs), memory T cells (CD4+/CD45RO), basophils, and eosinophils. The encoded chemokine protein functions as a ligand for CCR1, CCR3, and CCR5. RANTES inhibits the action of R5 strains of HIV-1 via blocking CCR5 receptor. A variant of RANTES gene is linked with susceptibility to HIV-1 infection and disease progression. Hence, this can be used as a potent biomarker to determine the prognosis of HIV -1 infection.
General description
Regulated on activation, normal T cell expressed and secreted (RANTES), also known as C-C motif chemokine ligand 5 (CCL5), is encoded by the gene mapped to human chromosome 17. RANTES belongs to the chemokine family of proinflammatory basic polypeptides and is expressed by various hematopoietic and non-hematopoietic cell types involved in homing and migration of effector and memory T cells during acute infections.
Physical form
Lyophilized from a 0.2 μm filtered solution in 35% acetonitrile and 0.1% trifluoroacetic acid containing 0.5 mg bovine serum albumin.
signalword
Danger
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2
存储类别
3 - Flammable liquids
wgk
WGK 2
flash_point_f
35.6 °F
flash_point_c
2 °C
法规信息
危险化学品
常规特殊物品
低风险生物材料
此项目有
A role for the chemokine RANTES in regulating CD8 T cell responses during chronic viral infection.
Crawford A
PLoS Pathogens (2011)
RANTES-activated human T lymphocytes. A role for phosphoinositide 3-kinase.
Journal of Immunology (1995)
Role of chemokine and cytokine polymorphisms in the progression of HIV-1 disease.
Biochemical and Biophysical Research Communications (2010)
Frequency of diagnosis of malignant melanoma.
Roth-Moyo L
Canadian Medical Association Journal (1977)
T J Schall et al.
Nature, 347(6294), 669-671 (1990-10-18)
An important process in the immune response is the migration of different populations of lymphocytes at the proper time to sites of antigenic challenge. Although several chemoattractants are known for broad classes of lymphocytes, such as T and B cells
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