Anti-phospho-Retinoblastoma (pSer^807,811) antibody produced in rabbit

RB1 (RB transcriptional corepressor 1) codes for nuclear phosphoprotein pRB (retinoblastoma protein). It is located on human chromosome 13q14. It is a tumor-suppressor gene.

Recognizes phosphorylated Rb (Ser⁸⁰⁷/Ser⁸¹¹) and does not react with non-phosphorylated Rb. Does not react with Rb phosphorylated at other sites.

synthetic peptide corresponding to residues around phosphoserine 807/811 of the human retinoblastoma tumor suppressor protein (Rb), conjugated to KLH.

Anti-phospho-Retinoblastoma (pSer807,811) has been used in western blotting.

RB1 (RB transcriptional corepressor 1) plays an important role throughout G1/S phase transition. Absence of RB induces prostate cancer metastasis. It plays an important role in modulating the cell cycle. It also regulates cell stemness and differentiation.

Solution in 10 mM sodium HEPES, pH 7.5, containing 150 mM sodium chloride, 100 μg/ml bovine serum albumin and 50% glycerol.

Purified using protein A and peptide affinity chromatography.

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