R6527
Reboxetine mesylate hydrate
>96% (HPLC), noradrenaline uptake inhibitor, solid
别名:
(2R)-rel-2-[(R)-(2-Ethoxyphenoxy)phenylmethyl]morpholine, Edronax, Vestra
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关于此项目
经验公式（希尔记法）:
C19H23NO3 · CH3SO3H · xH2O
化学文摘社编号:
分子量:
409.50 (anhydrous basis)
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
Reboxetine mesylate hydrate, >96% (HPLC), solid
SMILES string
O.CS(O)(=O)=O.CCOc1ccccc1O[C@@H]([C@H]2CNCCO2)c3ccccc3
InChI key
SZPHEVAYLIVGRC-BAMQSBMESA-N
InChI
1S/C19H23NO3.CH4O3S.H2O/c1-2-21-16-10-6-7-11-17(16)23-19(15-8-4-3-5-9-15)18-14-20-12-13-22-18;1-5(2,3)4;/h3-11,18-20H,2,12-14H2,1H3;1H3,(H,2,3,4);1H2/t18-,19-;;/m1../s1
assay
>96% (HPLC)
form
solid
storage condition
desiccated
color
white to tan
solubility
H2O: >5 mg/mL at ≤60 °C
shipped in
wet ice
storage temp.
2-8°C
Quality Level
Features and Benefits
This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Application
Reboxetine mesylate hydrate has been used as a selective norepinephrine transport blocker:
- to study its effects on the surge of dopamine in the cortex of mice brain
- to study its anti-immobility effects on the behavior of mice
- to analyze its effects on the probabilistic reversal learning task in rodents
Biochem/physiol Actions
Reboxetine mesylate hydrate is a selective noradrenaline uptake inhibitor.
Reboxetine exhibits anti-depressant activity.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Özgür Devrim Can et al.
European journal of pharmacology, 699(1-3), 250-257 (2012-10-27)
The present study was designed to investigate the putative effect of vitexin, a flavone C-glucoside present in some drugs, medicinal plants and nutraceuticals, on the central nervous system. Vitexin (10-30 mg/kg) did not show significant alterations in the behaviour of
Matthew P Wilkinson et al.
Brain and neuroscience advances, 4, 2398212820907177-2398212820907177 (2020-03-29)
Deficits in reward processing are a central feature of major depressive disorder with patients exhibiting decreased reward learning and altered feedback sensitivity in probabilistic reversal learning tasks. Methods to quantify probabilistic learning in both rodents and humans have been developed
Dennis K Miller et al.
The Journal of pharmacology and experimental therapeutics, 302(2), 687-695 (2002-07-20)
The present study determined whether repeated administration of the antidepressant and selective norepinephrine (NE) uptake inhibitor reboxetine resulted in an adaptive modification of the function of the NE transporters (NETs), serotonin (5-HT) transporters, or dopamine (DA) transporters. Because antidepressants may
Patrick Neiens et al.
Biomedical chromatography : BMC, 32(7), e4231-e4231 (2018-03-04)
MS Binding Assays represent a label-free alternative to radioligand binding assays. In this study, we present an LC-ESI-MS/MS method for the quantification of (R,R)-4-(2-benzhydryloxyethyl)-1-(4-fluorobenzyl)piperidin-3-ol [(R,R)-D-84, (R,R)-1], (S,S)-reboxetine [(S,S)-2], and (S)-citalopram [(S)-3] employed as highly selective nonlabeled reporter ligands in MS
Hagar Gelbard-Sagiv et al.
Current biology : CB, 28(14), 2239-2249 (2018-07-10)
An identical sensory stimulus may or may not be incorporated into perceptual experience, depending on the behavioral and cognitive state of the organism. What determines whether a sensory stimulus will be perceived? While different behavioral and cognitive states may share
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