R7150
Ro 25-6981 盐酸盐 水合物
≥98% (HPLC), powder
别名:
(αR)-(4-羟基苯基)-(βS)-甲基-4-(苯基甲基)-1-哌啶丙醇 盐酸盐 水合物
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C22H29NO2 · HCl · xH2O
化学文摘社编号:
分子量:
375.93 (anhydrous basis)
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
产品名称
Ro 25-6981 盐酸盐 水合物, ≥98% (HPLC), powder
SMILES string
O.Cl.C[C@@H](CN1CCC(CC1)Cc2ccccc2)[C@@H](O)c3ccc(O)cc3
InChI
1S/C22H29NO2.ClH.H2O/c1-17(22(25)20-7-9-21(24)10-8-20)16-23-13-11-19(12-14-23)15-18-5-3-2-4-6-18;;/h2-10,17,19,22,24-25H,11-16H2,1H3;1H;1H2/t17-,22+;;/m0../s1
InChI key
FEINQVNMUYISNW-HVDCVHHPSA-N
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white
solubility
DMSO: >20 mg/mL
originator
Roche
Quality Level
Gene Information
human ... GRIN2B(2904)
Application
Ro 25-6981盐酸水合物已被用于：
- 作为NR2B拮抗剂，用于微量注射大鼠，研究含NR2B和NR2A的N-甲基-D-天冬氨酸受体 (NMDAR) 对前额叶皮层 (PL) 痕迹和线索记忆形成的影响
- 作为NR2B拮抗剂，研究对新生大鼠SVZ中缺氧缺血性损伤NMDAR亚基2A和2B蛋白表达的影响
- 诱导对海马体记忆巩固和长时程增强 (LTP) 发生的损害作用
Biochem/physiol Actions
含有NR2B亚基的NMDA谷氨酸受体的有效和选择性拮抗剂。
Features and Benefits
该化合物是受体分类及信号转导手册上谷氨酸受体（离子通道家族）页面上的特色化合物。想要浏览手册的其他页面， 请单击此处。
这种化合物是神经科学研究的特色产品。点击此处发现更多特色神经科学产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
G Fischer et al.
The Journal of pharmacology and experimental therapeutics, 283(3), 1285-1292 (1998-02-12)
The interaction of Ro 25-6981 with N-methyl-D-aspartate (NMDA) receptors was characterized by a variety of different tests in vitro. Ro 25-6981 inhibited 3H-MK-801 binding to rat forebrain membranes in a biphasic manner with IC50 values of 0.003 microM and 149
NMDA receptors promote neurogenesis in the neonatal rat subventricular zone following hypoxic-ischemic injury
Lai Q, et al.
Molecular Medicine Reports, 13(1), 206-212 (2016)
NR2A-and NR2B-containing NMDA receptors in the prelimbic medial prefrontal cortex differentially mediate trace, delay, and contextual fear conditioning
Gilmartin MR, et al.
Learning & Memory, 20(6), 290-294 (2013)
Ya-Bing Zhu et al.
Journal of neuropathology and experimental neurology, 79(7), 800-808 (2020-05-10)
The mechanisms underlying type-2 diabetic neuropathic pain (DNP) are unclear. This study investigates the coupling of postsynaptic density-95 (PSD-95) to N-methyl-D-aspartate receptor subunit 2B (GluN2B), and the subsequent phosphorylation of GluN2B (Tyr1472-GluN2B) in the spinal cord in a rat model
Zhong Di et al.
Evidence-based complementary and alternative medicine : eCAM, 2021, 5370214-5370214 (2021-11-05)
Stroke is a common and frequently occurring disease of the central nervous system, which is characterized by high mortality and a high disability rate. Moxibustion is a common method for treating stroke in traditional Chinese medicine, but its neuroprotective mechanism
商品
DISCOVER Bioactive Small Molecules for Neuroscience
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持