R8526
RO-52 (SSA) human
recombinant, expressed in E. coli, liquid
别名:
Anti-RO-52 antibody
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关于此项目
Form:
liquid
Biological source:
human
Recombinant:
expressed in E. coli
Mol wt:
52 kDa by SDS-PAGE
biological source
human
recombinant
expressed in E. coli
form
liquid
mol wt
52 kDa by SDS-PAGE
technique(s)
ELISA: suitable
UniProt accession no.
storage temp.
−70°C
Quality Level
Gene Information
human ... TRIM21(6737)
General description
Research area: Cell Signaling
RO-52 (SSA), also called as tripartite motif-containing protein 21 (TRIM21) is a 52 kDa, ubiquitin E3 ligase. It has a N-terminal RING finger domain (Really Interesting New Gene), crucial for ubiquitination functionality. RO-52 (SSA) gene is mapped to human chromosome 11p5.5.
RO-52 (SSA), also called as tripartite motif-containing protein 21 (TRIM21) is a 52 kDa, ubiquitin E3 ligase. It has a N-terminal RING finger domain (Really Interesting New Gene), crucial for ubiquitination functionality. RO-52 (SSA) gene is mapped to human chromosome 11p5.5.
Application
RO-52 (SSA) human has been used:
- as a component of the autoantigen array
- to immobilise protein on the self-assembly monolayer
- in enzyme-linked immunosorbent assays (ELISAs)
Biochem/physiol Actions
RO-52 (SSA) is capable of autoubiquitination and uniquitylates p62 protein and regulates redox homeostasis.Patients with Sjogren′s syndrome display elevated levels of anti-Ro/SSA antibodies. RO-52 levels in peripheral blood mononuclear cells (PBMC) contributes to pathogenesis of systemic lupus erythematosus (SLE), systemic autoimmune rheumatic diseases (SARDs), interstitial lung disease (ILD) and connective tissue diseases (CTD). RO-52 is considered as potential target for treating SLE.
Used for the detection and quantification of antibodies to RNPs in rheumatic diseases.
Physical form
solution contains 20 mM phosphate buffer, 500 mM NaCl, 2M - 3M urea, pH 6.
存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
The Sjogren?s syndrome-associated autoantigen Ro52 is an E3 ligase that regulates proliferation and cell death
Espinosa A, et al.
Journal of Immunology, 176(10), 6277-6285 (2006)
Mapping molecular binding by means of conformational dynamics measurements
do Nascimento NM, et al.
Royal Society of Chemistry Advances, 8(2), 867-876 (2018)
Electronic Structure Calculation and Superconductivity in lambda-(BETS) 2GaCl4
Aizawa H, et al.
Journal of the Physical Society of Japan, 87(9), 093701-093701 (2018)
Serological epitope profile of anti-Ro52-positive patients with systemic autoimmune rheumatic diseases
Infantino M, et al.
Arthritis Research & Therapy, 17(1), 365-365 (2015)
Autoantigen TRIM21/Ro52 as a possible target for treatment of systemic lupus erythematosus
Yoshimi R, et al.
International journal of rheumatology, 2012, 6277-6285 (2012)
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