R8657

Razoxane

Name: Razoxane
Brand: SIGMA

>98% (HPLC)

别名:

(±)-1,2-Bis(3,5-dioxopiperazin-1-yl)propane, (±)-1,2-Bis(3,5-dioxopiperazinyl)propane, 1,2-Bis(3,5-dioxo-1-piperazinyl)propane, 4,4′-Propylenebis(2,6-piperazinedione), ICI 59118, ICRF 159, NSC 129943, Razoxin, Tepirone, Troxozone

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About This Item

经验公式（希尔记法）:

C₁₁H₁₆N₄O₄

CAS Number:

21416-67-1

分子量:

268.27

EC 号:

244-379-2

MDL编号:

MFCD00430424

UNSPSC代码:

12352200

PubChem化学物质编号:

329824039

NACRES:

NA.77

主要文件

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质量水平

100

方案

>98% (HPLC)

表单

solid

溶解性

DMSO: 40 mg/mL

储存温度

room temp

SMILES字符串

CC(CN1CC(=O)NC(=O)C1)N2CC(=O)NC(=O)C2

InChI

1S/C11H16N4O4/c1-7(15-5-10(18)13-11(19)6-15)2-14-3-8(16)12-9(17)4-14/h7H,2-6H2,1H3,(H,12,16,17)(H,13,18,19)

InChI key

BMKDZUISNHGIBY-UHFFFAOYSA-N

生化/生理作用

Razoxane is clinically active against angiogenesis and metastasis. Razoxane specifically inhibits topoisomerase II without inducing DNA strand breaks (topo II catalytic inhibitor). It is an antimitotic agent with immunosuppressive properties. Razoxane inhibits blood-borne and lymphatic metastases in different experimental models. Studies have shown that razoxane inhibits specifically the vasculogenic mimicry of B16F10 melanoma cells.

Razoxane is clinically active against angiogenesis and metastasis; inhibits topoisomerase II without inducing DNA strand breaks (topo II catalytic inhibitor).