产品名称
雷帕霉素, Ready Made Solution, 2.5 mg/mL in DMSO (2.74 mM), from Streptomyces hygroscopicus
biological source
Streptomyces hygroscopicus
vapor pressure
0.56 hPa ( 20 °C)
assay
≥95% (HPLC)
form
solution
autoignition temp.
301 °C
concentration
2.5 mg/mL in DMSO (2.74 mM)
color
colorless to yellow
antibiotic activity spectrum
fungi
yeast
mode of action
enzyme | inhibits
storage temp.
−20°C
Quality Level
Application
雷帕霉素已被用于:
- 作为mTeSR1培养基的补充剂，用于培养诱导多能干细胞（iPSC）集落以诱导自噬信号传导
- 处理65-70%汇合度的果蝇S2细胞
- 测定蛋白质合成
- 刺激卵巢癌症细胞的自噬
General description
雷帕霉素是一种mTOR抑制剂，来源于吸水链霉菌。它可以抑制病毒复制。这种天然抗真菌抗生素已被证明是一种抗衰老剂。雷帕霉素显著抑制mTORC1，无论年龄大小都有效。
雷帕霉素是一种具有有效的免疫抑制剂和抗癌活性的大环三烯抗生素。它可与FKBP12形成能与雷帕霉素分子靶标（mTOR）结合并对其进行抑制的复合物。mTOR是磷酸肌醇激酶相关激酶（PIKK）家族的成员，该家族可通过磷酸肌醇3-激酶/Akt信号通路增强细胞增殖。通过雷帕霉素阻断可导致G1细胞周期阻滞的下游元素而对该通路进行抑制。mTOR作用的效应子包括4EBP1和S6K1。
Other Notes
保存于密闭容器内，置于干燥通风处。惰性气体中保存。是吸湿性的。
雷帕霉素已经过专家审查并被化学探针门户网站所推荐。如需更多信息，请访问化学探针门户网站上的雷帕霉素探针摘要。
雷帕霉素已经过专家审查并被化学探针门户网站所推荐。如需更多信息，请访问化学探针门户网站上的雷帕霉素探针摘要。
Packaging
200uL
存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
188.6 °F - closed cup
flash_point_c
87 °C - closed cup
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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商品
Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.
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