产品名称
Ro 8-4304, solid
InChI
1S/C21H23FN2O3.ClH/c22-18-5-1-15(2-6-18)16-9-12-24(13-10-16)20(25)11-14-27-19-7-3-17(4-8-19)21(23)26;/h1-9,20,25H,10-14H2,(H2,23,26);1H
SMILES string
Cl.NC(=O)c1ccc(OCCC(O)N2CCC(=CC2)c3ccc(F)cc3)cc1
InChI key
NYFXHCMXYODFLP-UHFFFAOYSA-N
form
solid
solubility
H2O: ≤0.5 mg/mL
originator
Roche
storage temp.
2-8°C
Quality Level
Gene Information
human ... GRIN2B(2904)
Biochem/physiol Actions
NR2B-selective, noncompetitive NMDA glutamate receptor antagonist
Features and Benefits
This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
Shuai Huang et al.
Molecular plant, 9(12), 1620-1633 (2016-10-21)
Nucleotide-binding leucine-rich repeat (NLR) proteins serve as immune receptors in both plants and animals. To identify components required for NLR-mediated immunity, we designed and carried out a chemical genetics screen to search for small molecules that can alter immune responses
Ghelardini, C., et al.
Drug Development Research, 40, 251-258 (1997)
Neuronal nicotinic acetylcholine receptors as novel drug targets.
G K Lloyd et al.
The Journal of pharmacology and experimental therapeutics, 292(2), 461-467 (2000-01-20)
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