R9525
RX 821002 hydrochloride
solid, ≥98% (HPLC)
别名:
2-[2-(2-Methoxy-1,4-benzodioxanyl)]imidazoline hydrochloride
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关于此项目
经验公式（希尔记法）:
C12H14N2O3 · HCl
化学文摘社编号:
分子量:
270.71
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Quality Level
assay
≥98% (HPLC)
form
solid
storage condition
desiccated
color
white
solubility
H2O: >20 mg/mL
SMILES string
Cl[H].COC1(COc2ccccc2O1)C3=NCCN3
InChI
1S/C12H14N2O3.ClH/c1-15-12(11-13-6-7-14-11)8-16-9-4-2-3-5-10(9)17-12;/h2-5H,6-8H2,1H3,(H,13,14);1H
InChI key
IMPOOMVZVWKSAP-UHFFFAOYSA-N
Gene Information
human ... ADRA2A(150), ADRA2B(151), ADRA2C(152)
Biochem/physiol Actions
Selective α2-adrenoceptor antagonist
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Thiago Roberto Lima Romero et al.
European journal of pharmacology, 608(1-3), 23-27 (2009-02-25)
Xylazine is an alpha(2)-adrenoceptor agonist extensively used in veterinary and animal experimentation. Evidence exists that alpha(2)-adrenoceptor agonists can activate opioid receptors via endogenous opioid release. Considering this idea and the multiple alpha(2) subtypes currently known (alpha(2A), alpha(2B), alpha(2C) and alpha(2D))
R L Almeida et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 301(1), R185-R192 (2011-04-09)
Lipopolysaccharide (LPS), an endotoxin from the wall of Escherichia coli, produces a general behavioral inhibition and affects several aspects of fluid-electrolyte balance. LPS inhibits thirst; however, it is not clear if it also inhibits sodium appetite. The present results show
Axel Rominger et al.
Synapse (New York, N.Y.), 64(8), 654-657 (2010-03-26)
To test for alpha(2) adrenergic modulation of dopamine D(2/3) receptor availability in striatum of living mice using the high-affinity ligand [(18)F]fallypride and microPET. Groups of anesthetized mice were pretreated with saline, the alpha(2)-agonist clonidine (1 mg/kg), and the alpha(2)-antagonists RX821002
J Galitzky et al.
British journal of pharmacology, 100(4), 862-866 (1990-08-01)
1. The binding of a new alpha 2-adrenoceptor antagonist, [3H]-RX821002 (2-(2-methoxy-1,4-benzodioxan-2-yl)-2-imidazoline), was investigated in human platelet membranes and compared with [3H]-yohimbine binding parameters. 2. Analysis of kinetic data revealed association and dissociation time courses consistent with a simple biomolecular reaction.
A Bai et al.
Clinical and experimental immunology, 156(2), 353-362 (2009-03-03)
Inflammatory bowel disease (IBD) is characterized by heavy production of proinflammatory cytokines such as tumour necrosis factor (TNF)-alpha and interleukin (IL)-1beta. Interactions of the autonomic nervous system with local immune cells play an important role in the development of IBD
商品
Learn about alpha-2 adrenoceptor and its subtypes, mediated responses, and applications of agonists. Included is a list of available products and a comparison table.
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| R9525-50MG | 04061832093239 |
| R9525-250MG | 04061832084473 |
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