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Merck
CN

R9782

Sigma-Aldrich

RS-1

≥98% (HPLC), RAD51 stimulator, powder

别名:

3-[（苄基氨基）磺酰基]-4-溴-N-（4-溴苯基）苯甲酰胺, 4-溴-N-（4-溴苯基）-3 - [[（苯基甲基）氨基]磺酰基]-苯甲酰胺, RAD51 刺激性化合物 1

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关于此项目

经验公式（希尔记法）:
C20H16Br2N2O3S
化学文摘社编号:
312756-74-4
分子量:
524.23
MDL编号:
MFCD00348720
UNSPSC代码:
12352200
PubChem化学物质编号:
329824048
NACRES:
NA.77

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产品名称

RS-1, ≥98% (HPLC)

质量水平

100

方案

≥98% (HPLC)

表单

powder

颜色

off-white to light tan

溶解性

DMSO: ≥10 mg/mL

储存温度

room temp

SMILES字符串

Brc1ccc(NC(=O)c2ccc(Br)c(c2)S(=O)(=O)NCc3ccccc3)cc1

InChI

1S/C20H16Br2N2O3S/c21-16-7-9-17(10-8-16)24-20(25)15-6-11-18(22)19(12-15)28(26,27)23-13-14-4-2-1-3-5-14/h1-12,23H,13H2,(H,24,25)

InChI key

SWKAVEUTKGKHSR-UHFFFAOYSA-N

相关类别

应用

RS-1已被：
  • 作为同源介导修复(HDR)激动剂，研究对人造血干细胞/祖细胞的影响(HSPC)
  • 作为HDR激动剂，分析其对人诱导多能干细胞(iPS) DNA修复调节的影响
  • 作为RAD51激动剂，研究对双链断裂修复的影响

RS-1显示出具有提高CRISPR基因组编辑效率的作用。欲了解其他CRISPR增强剂小分子，请访问 sigma.com/CRISPR-enhancers

生化/生理作用

RS-1 是人同源重组蛋白 RAD51 的刺激物。
RS-1是一种磺酰胺-苯甲酰胺化合物。
RS-1（RAD51-刺激性化合物1）是人同源重组（HR）蛋白 RAD51 的刺激物。RS-1 刺激 hRAD51 与单链 DNA（ssDNA）的结合，并且在不抑制 hRAD51 ATP 酶活性的情况下，通过稳定 hRAD51 微丝的活性形式来增强重组活性。研究表明，RS-1 可增强 HEK293A 细胞中 CRISPR-Cas9 的敲入效率，并且在兔中，它可以提高 TALEN 和 cas9 介导的敲入效率。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000201249
0000062716
0000062717
119K4711V
0000201249

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商品

CRISPR小分子增强剂

业内研究了CRISPR基因组编辑背景下的HDR调控，发现各种细胞类型中增强CRISPR介导的HDR效率的小分子。

Small Molecule CRISPR Enhancers

Modulation of homology-directed repair (HDR) within the context of CRISPR-genome editing has led to the identification of small molecules that enhance CRISPR-mediated HDR efficiency in various cell types.

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