R9782
RS-1
≥98% (HPLC), RAD51 stimulator, powder
别名:
3-[（苄基氨基）磺酰基]-4-溴-N-（4-溴苯基）苯甲酰胺, 4-溴-N-（4-溴苯基）-3 - [[（苯基甲基）氨基]磺酰基]-苯甲酰胺, RAD51 刺激性化合物 1
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关于此项目
经验公式（希尔记法）:
C20H16Br2N2O3S
化学文摘社编号:
分子量:
524.23
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
产品名称
RS-1, ≥98% (HPLC)
方案
≥98% (HPLC)
表单
powder
颜色
off-white to light tan
溶解性
DMSO: ≥10 mg/mL
储存温度
room temp
SMILES字符串
Brc1ccc(NC(=O)c2ccc(Br)c(c2)S(=O)(=O)NCc3ccccc3)cc1
InChI
1S/C20H16Br2N2O3S/c21-16-7-9-17(10-8-16)24-20(25)15-6-11-18(22)19(12-15)28(26,27)23-13-14-4-2-1-3-5-14/h1-12,23H,13H2,(H,24,25)
InChI key
SWKAVEUTKGKHSR-UHFFFAOYSA-N
相关类别
应用
RS-1已被：
- 作为同源介导修复(HDR)激动剂，研究对人造血干细胞/祖细胞的影响(HSPC)
- 作为HDR激动剂，分析其对人诱导多能干细胞(iPS) DNA修复调节的影响
- 作为RAD51激动剂，研究对双链断裂修复的影响
RS-1显示出具有提高CRISPR基因组编辑效率的作用。欲了解其他CRISPR增强剂小分子，请访问 sigma.com/CRISPR-enhancers
生化/生理作用
RS-1 是人同源重组蛋白 RAD51 的刺激物。
RS-1是一种磺酰胺-苯甲酰胺化合物。
RS-1（RAD51-刺激性化合物1）是人同源重组（HR）蛋白 RAD51 的刺激物。RS-1 刺激 hRAD51 与单链 DNA（ssDNA）的结合，并且在不抑制 hRAD51 ATP 酶活性的情况下，通过稳定 hRAD51 微丝的活性形式来增强重组活性。研究表明，RS-1 可增强 HEK293A 细胞中 CRISPR-Cas9 的敲入效率，并且在兔中，它可以提高 TALEN 和 cas9 介导的敲入效率。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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Cisplatin can damage spiral ganglion neurons (SGNs) and cause sensorineural hearing loss. Wnt activation protects against neomycin-induced hair cell damage in the mouse cochlea, but the role of Wnt signaling in protecting SGNs from cisplatin treatment has not yet been
Jordan Pinder et al.
Nucleic acids research, 43(19), 9379-9392 (2015-10-03)
CRISPR is a genome-editing platform that makes use of the bacterially-derived endonuclease Cas9 to introduce DNA double-strand breaks at precise locations in the genome using complementary guide RNAs. We developed a nuclear domain knock-in screen, whereby the insertion of a
Krishanthi Jayathilaka et al.
Proceedings of the National Academy of Sciences of the United States of America, 105(41), 15848-15853 (2008-10-09)
RAD51 and other members of the RecA family of strand exchange proteins assemble on ssDNA to form presynaptic filaments, which carry out the central steps of homologous recombination. A microplate-based assay was developed for high-throughput measurement of hRAD51 filament formation
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Modulation of homology-directed repair (HDR) within the context of CRISPR-genome editing has led to the identification of small molecules that enhance CRISPR-mediated HDR efficiency in various cell types.
业内研究了CRISPR基因组编辑背景下的HDR调控，发现各种细胞类型中增强CRISPR介导的HDR效率的小分子。
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