R9782
RS-1
≥98% (HPLC), RAD51 stimulator, powder
别名:
3-[（苄基氨基）磺酰基]-4-溴-N-（4-溴苯基）苯甲酰胺, 4-溴-N-（4-溴苯基）-3 - [[（苯基甲基）氨基]磺酰基]-苯甲酰胺, RAD51 刺激性化合物 1
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关于此项目
经验公式（希尔记法）:
C20H16Br2N2O3S
化学文摘社编号:
分子量:
524.23
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
RS-1, ≥98% (HPLC)
SMILES string
Brc1ccc(NC(=O)c2ccc(Br)c(c2)S(=O)(=O)NCc3ccccc3)cc1
InChI key
SWKAVEUTKGKHSR-UHFFFAOYSA-N
InChI
1S/C20H16Br2N2O3S/c21-16-7-9-17(10-8-16)24-20(25)15-6-11-18(22)19(12-15)28(26,27)23-13-14-4-2-1-3-5-14/h1-12,23H,13H2,(H,24,25)
assay
≥98% (HPLC)
form
powder
color
off-white to light tan
solubility
DMSO: ≥10 mg/mL
storage temp.
room temp
Quality Level
相关类别
Application
RS-1已被：
- 作为同源介导修复(HDR)激动剂，研究对人造血干细胞/祖细胞的影响(HSPC)
- 作为HDR激动剂，分析其对人诱导多能干细胞(iPS) DNA修复调节的影响
- 作为RAD51激动剂，研究对双链断裂修复的影响
RS-1显示出具有提高CRISPR基因组编辑效率的作用。欲了解其他CRISPR增强剂小分子，请访问 sigma.com/CRISPR-enhancers
Biochem/physiol Actions
RS-1 是人同源重组蛋白 RAD51 的刺激物。
RS-1是一种磺酰胺-苯甲酰胺化合物。
RS-1（RAD51-刺激性化合物1）是人同源重组（HR）蛋白 RAD51 的刺激物。RS-1 刺激 hRAD51 与单链 DNA（ssDNA）的结合，并且在不抑制 hRAD51 ATP 酶活性的情况下，通过稳定 hRAD51 微丝的活性形式来增强重组活性。研究表明，RS-1 可增强 HEK293A 细胞中 CRISPR-Cas9 的敲入效率，并且在兔中，它可以提高 TALEN 和 cas9 介导的敲入效率。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Modulation of homology-directed repair (HDR) within the context of CRISPR-genome editing has led to the identification of small molecules that enhance CRISPR-mediated HDR efficiency in various cell types.
业内研究了CRISPR基因组编辑背景下的HDR调控，发现各种细胞类型中增强CRISPR介导的HDR效率的小分子。
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