RAB0161
磷酸化EGFR（pSer 1070）ELISA试剂盒
for detection of human, mouse or rat phospho-egfr (pSer1070) in cell and tissue lysates
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关于此项目
NACRES:
NA.32
UNSPSC Code:
41116158
Gene information:
human ... EGFR(1965)
Input:
sample type tissue lysate
sample type cell lysate
sample type cell lysate
Species reactivity:
mouse, human, rat
Storage temp.:
−20°C
Shipped in:
wet ice
产品名称
磷酸化EGFR（pSer 1070）ELISA试剂盒, for detection of human, mouse or rat phospho-egfr (pSer1070) in cell and tissue lysates
species reactivity
mouse, human, rat
technique(s)
ELISA: suitable
capture ELISA: suitable
input
sample type tissue lysate
sample type cell lysate
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... EGFR(1965)
Application
请参考Protocol了解详情。
Biochem/physiol Actions
The members of epidermal growth factor receptor (EGF R) or the ErbB receptor family have been identified as useful biomarkers and targets for cancer therapy. EGF R binds EGF and induces tyrosine phosphorylation leading to proliferation of cells. EGF R is capable of binding transforming growth factor-α and heparin-binding EGF in addition to EGF. There are numerous effector molecules activated by EGF R that result in a variety of biological processes such as morphogenesis, cell motility, apoptosis, differentiation and organ repair and maintenance. Deregulation of EGF R signaling is implicated in progression of a wide variety of tumors, invasion and metastasis. Phosphorylation of Tyr1068 occurs by autophosphorylation of EGF R and is required for the binding of Grb2 (Growth factor receptor-bound protein 2) and activation of ERK1/2 (extracellular signal-regulated kinases) pathway.
General description
The Human BLC ELISA (Enzyme-Linked Immunosorbent Assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human BLC in serum, plasma, cell culture supernatants and urine.
The EGFR (epidermal growth factor receptor) family includes four receptor tyrosine kinases, EGF R (ErbB1), ErbB2 (neu), ErbB3, and ErbB4. EGF R is present on many cell types of epithelial and mesenchymal lineages. The gene EGFR is mapped to human chromosome 7p11.2.
The EGFR (epidermal growth factor receptor) family includes four receptor tyrosine kinases, EGF R (ErbB1), ErbB2 (neu), ErbB3, and ErbB4. EGF R is present on many cell types of epithelial and mesenchymal lineages. The gene EGFR is mapped to human chromosome 7p11.2.
Immunogen
EGFR (pTyr1070) synthetic phosphopeptide
signalword
Warning
hcodes
Hazard Classifications
Met. Corr. 1 - STOT SE 3
target_organs
Respiratory system
存储类别
8A - Combustible corrosive hazardous materials
法规信息
新产品
此项目有
The Eps8 protein coordinates EGF receptor signalling through Rac and trafficking through Rab5.
Lanzetti L, et al.
Nature, 408(6810), 374-374 (2000)
EGF receptor.
Wells A
The International Journal of Biochemistry & Cell Biology, 31(6), 637-643 (1999)
Landscape of EGFR signaling network in human cancers: biology and therapeutic response in relation to receptor subcellular locations.
Han W and Lo H W
Cancer Letters, 318(2), 124-134 (2012)
Targeting the EGFR signaling pathway in cancer therapy.
Seshacharyulu P, et al.
Expert Opinion on Therapeutic Targets, 16(1), 15-31 (2012)
Chromosome 7p11.2 (EGFR) variation influences glioma risk.
Sanson M, et al.
Human Molecular Genetics, 20(14), 2897-2904 (2011)
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