Merck
CN

RAB0166

Sigma-Aldrich

磷酸化EGFR(pTyr1068) 和pan-EGFR ELISA试剂盒

for detection of human phospho-egfr (pTyr1068) and pan-egfr in cell and tissue lysates

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NACRES:
NA.32

种属反应性

human

包装

kit of 96 wells (12 strips x 8 wells)

技术

ELISA: suitable
capture ELISA: suitable

输入

sample type: human cell lysate
sample type: human tissue lysate

检测方法

colorimetric

运输

wet ice

储存温度

−20°C

基因信息

human ... EGFR(1965)

一般描述

The Phospho-EGFR (pTyr1068) ELISA (Enzyme-Linked Immunosorbent Assay) kit is a very rapid, convenient and sensitive assay kit that can monitor the activation or function of important biological pathways in cell lysates.

免疫原

EGFR (pTyr1068) synthetic phosphopeptide, Recombinant Human EGFR

应用

请参考Protocol了解详情。

生化/生理作用

EGFR (epidermal growth factor receptor) functions as a receptor for EGF-family of proteins, which are peptide growth factors. This receptor-ligand system is also involved in the pathogenesis and progression of various types of carcinomas. In cancer, EGFR pathways promotes cellular proliferation, angiogenesis, metastasis and apoptosis. The microRNA miR-218-5p interacts with and controls EGFR, and in non-small cell lung cancer (NSCLC), the levels of EGFR are inversely related to miR-218-5p. miR-218-5p inhibits proliferation and migration of lung cancer cells by binding with EGFR, and thus, has potential in future NSCLC therapies. Phospho-EGFR activates phospho-Akt pathway in invasive bladder cancer (BC) and it can be considered as a promising therapeutic target for cancer.

其他说明

Phosphorylated and pan protien can both be measured , in one experimnet.

象形图

Corrosion

警示用语:

Warning

危险声明

预防措施声明

危险分类

Met. Corr. 1

储存分类代码

8B - Non-combustible, corrosive hazardous materials

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

新产品

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示例

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Phospho-Akt pathway activation and inhibition depends on N-cadherin or phospho-EGFR expression in invasive human bladder cancer cell lines.
Wallerand H
Urologic Oncology, 28(2), 180-188 (2010)
Tumor-suppressive miR-218-5p inhibits cancer cell proliferation and migration via EGFR in non-small cell lung cancer.
Zhu K, et al.
Oncotarget, 7(19), 28075-28085 (2016)
Epidermal growth factor receptor (EGFR) signaling in cancer.
Normanno N
Gene, 366(1), 2-16 (2006)
A novel approach in the treatment of cancer: targeting the epidermal growth factor receptor.
Ciardiello F, Tortora G
Clinical Cancer Research, 7(10), 2958-2970 (2001)

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