RAB0166
磷酸化EGFR（pTyr1068) 和pan-EGFR ELISA试剂盒
for detection of human phospho-egfr (pTyr1068) and pan-egfr in cell and tissue lysates
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关于此项目
NACRES:
NA.32
UNSPSC Code:
41116158
Gene information:
human ... EGFR(1965)
Input:
sample type: human cell lysate
sample type: human tissue lysate
sample type: human tissue lysate
Species reactivity:
human
Storage temp.:
−20°C
Shipped in:
wet ice
产品名称
磷酸化EGFR（pTyr1068) 和pan-EGFR ELISA试剂盒, for detection of human phospho-egfr (pTyr1068) and pan-egfr in cell and tissue lysates
species reactivity
human
packaging
kit of 96 wells (12 strips x 8 wells)
technique(s)
ELISA: suitable
capture ELISA: suitable
input
sample type: human cell lysate
sample type: human tissue lysate
detection method
colorimetric
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... EGFR(1965)
Application
请参考Protocol了解详情。
Biochem/physiol Actions
EGFR (epidermal growth factor receptor) functions as a receptor for EGF-family of proteins, which are peptide growth factors. This receptor-ligand system is also involved in the pathogenesis and progression of various types of carcinomas. In cancer, EGFR pathways promotes cellular proliferation, angiogenesis, metastasis and apoptosis. The microRNA miR-218-5p interacts with and controls EGFR, and in non-small cell lung cancer (NSCLC), the levels of EGFR are inversely related to miR-218-5p. miR-218-5p inhibits proliferation and migration of lung cancer cells by binding with EGFR, and thus, has potential in future NSCLC therapies. Phospho-EGFR activates phospho-Akt pathway in invasive bladder cancer (BC) and it can be considered as a promising therapeutic target for cancer.
General description
The Phospho-EGFR (pTyr1068) ELISA (Enzyme-Linked Immunosorbent Assay) kit is a very rapid, convenient and sensitive assay kit that can monitor the activation or function of important biological pathways in cell lysates.
Immunogen
EGFR (pTyr1068) synthetic phosphopeptide, Recombinant Human EGFR
Other Notes
Phosphorylated and pan protien can both be measured , in one experimnet.
signalword
Warning
hcodes
pcodes
Hazard Classifications
Met. Corr. 1
存储类别
8B - Non-combustible corrosive hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Phospho-Akt pathway activation and inhibition depends on N-cadherin or phospho-EGFR expression in invasive human bladder cancer cell lines.
Wallerand H
Urologic Oncology, 28(2), 180-188 (2010)
Tumor-suppressive miR-218-5p inhibits cancer cell proliferation and migration via EGFR in non-small cell lung cancer.
Zhu K, et al.
Oncotarget, 7(19), 28075-28085 (2016)
Epidermal growth factor receptor (EGFR) signaling in cancer.
Normanno N
Gene, 366(1), 2-16 (2006)
A novel approach in the treatment of cancer: targeting the epidermal growth factor receptor.
Ciardiello F, Tortora G
Clinical Cancer Research, 7(10), 2958-2970 (2001)
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