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安全信息

RAB0361

Sigma-Aldrich

Human MMP-1 ELISA Kit

for serum, plasma, cell culture supernatant and urine

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别名:
MMP-1, Matrix metalloproteinase-1
NACRES:
NA.32

种属反应性

human

包装

kit of 96 wells (12 strips x 8 wells)

技术

ELISA: suitable
capture ELISA: suitable

输入

sample type plasma
sample type cell culture supernatant(s)
sample type serum
sample type urine

assay range

inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 8 pg/mL
standard curve range: 24.69-18000 pg/mL

检测方法

colorimetric

运输

wet ice

储存温度

−20°C

基因信息

human ... MMP1(4312)

相关类别

一般描述

The Human MMP-1 ELISA (Enzyme-Linked Immunosorbent Assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human MMP-1 pro and active forms in serum, plasma, cell culture supernatants and urine.

免疫原

Recombinant Human MMP1

应用

For research use only. Not for use in diagnostic procedures.
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)
Human MMP-1 ELISA Kit has been used in ELISA assays.

生化/生理作用

Matrix metalloproteinases (MMPs) enzymes play a central role in the maintenance and remodeling of the extracellular matrix. Elevated expression of their activity, caused either by up-regulation of their expression or down-regulation of their cognate inhibitors, has been implicated in various degenerative disorders, including arthritis, cardiovascular disease, skeletal growth-plate disorders, and cancer metastasis. MMP-1 is a secreted collagenase with specificity toward Type I, II, III, VII, and X collagens, aggrecan, serpins, and α2-macroglobulin. It is overexpressed in lumbar intervertebral disc degeneration (IDD). It might also be associated with osteoarthritis. MMP-1 is linked with juvenile idiopathic arthritis. Genetic variations in MMP-1 can affect the susceptibility and severity of this disease.

其他说明

A sample Certificate of Analysis is available for this product.
Please type the word sample in the text box provided for lot number.

试剂盒组分也可单独购买

产品编号
说明
化学品安全说明书
  • RABELADEELISA 5X Assay/Sample Diluent Buffer E (Item E2)化学品安全说明书
  • RABSTOP3ELISA Stop Solution (Item I)化学品安全说明书
  • RABTMB3ELISA Colorimetric TMB Reagent (HRP Substrate, Item H)化学品安全说明书
  • RABWASH420X Wash Buffer (Item B)化学品安全说明书

象形图

Corrosion
GHS05

警示用语：

Warning

危险声明

H290

预防措施声明

P234 - P390

危险分类

Met. Corr. 1

储存分类代码

8B - Non-combustible, corrosive hazardous materials

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

常规特殊物品

分析证书(COA)

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示例

T1503
货号
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25G
包装规格/数量

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索取COA

Regulation of matrix metalloproteinase expression in tumor invasion.
Westermarck J and Kahari VM
FEBS Journal, 13, 781-792 (1999)
Expression profiles of MMP-1 and TIMP-1 in lumbar intervertebral disc degeneration.
Deng B, et. al.
Genetics and molecular research : GMR, 14, 19080-19086 (2015)
Matrix metalloproteinases: role in skeletal development and growth plate disorders.
Malemud CJ
Frontiers in Bioscience, 11, 1702-1715 (2006)
Transcriptional regulation of collagenase (MMP-1, MMP-13) genes in arthritis: integration of complex signaling pathways for the recruitment of gene-specific transcription factors.
Vincenti MP and Brinckerhoff CE
Arthritis Research, 4, 157-164 (2002)
The development of a matrix metalloproteinase-1 biosensor based on the surface plasmon resonance imaging technique
Tokarzewicz A, et al.
Analytical Methods : Advancing Methods and Applications, 8(34), 428-6435 (2016)
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