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安全信息

RAB0500

Sigma-Aldrich

Human p53 ELISA Kit

for serum, plasma, cell culture supernatant and urine

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NACRES:
NA.32

species reactivity

human

包装

kit of 96 wells (12 strips x 8 wells)

technique(s)

ELISA: suitable
capture ELISA: suitable

input

sample type cell culture supernatant(s)
sample type urine
sample type serum
sample type plasma

assay range

inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 0.3 ng/mL
standard curve range: 0.328-80 ng/mL

detection method

colorimetric

运输

wet ice

储存温度

−20°C

Gene Information

human ... TP53(7157)

相关类别

一般描述

Cellular tumor antigen p53 is a tumor-suppressor protein that comprises transactivation at N-terminus, central sequence-specific DNA-binding domain, and regulatory domain at C-terminus. It plays a key role in autophagy regulation. It inhibits tumors and acts as a cellular stress sensor especially during nutrient deprivation, hypoxia, and ribosome dysfunction. The Human p-53 ELISA (Enzyme-Linked Immunosorbent Assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human p-53 in serum, plasma, cell culture supernatants and urine.

免疫原

Recombinant Human p53

应用

For research use only. Not for use in diagnostic procedures.
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)
Human p53 ELISA Kit has been used for quantifying p53 using enzyme-linked immunosorbent assay (ELISA) in human myeloma RPMI-8226 cells, human colorectal cancer HCT-116 cells, human breast cancer MCF-7 cells and human leukemiaHL-60 cells.

其他说明

A sample Certificate of Analysis is available for this product.
Please type the word sample in the text box provided for lot number.

试剂盒组分也可单独购买

产品编号
说明
化学品安全说明书
  • RABELADBELISA 5X Assay/Sample Diluent Buffer B (Item E1)化学品安全说明书
  • RABELADDELISA 5X Assay/Sample Diluent Buffer D (Item K)化学品安全说明书
  • RABSTOP3ELISA Stop Solution (Item I)化学品安全说明书
  • RABTMB3ELISA Colorimetric TMB Reagent (HRP Substrate, Item H)化学品安全说明书
  • RABWASH420X Wash Buffer (Item B)化学品安全说明书

象形图

Corrosion
GHS05

警示用语：

Warning

危险声明

H290

预防措施声明

P234 - P390

危险分类

Met. Corr. 1

储存分类代码

8A - Combustible, corrosive hazardous materials

WGK

WGK 3

法规信息

常规特殊物品

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Evaluation of roscovitine anticancer agent as a reference compound for cancer and apoptosis studies
Taha H, et al.
JIMD Reports null
Mohammed K Abd Elhameid et al.
Chemical & pharmaceutical bulletin, 66(10), 939-952 (2018-08-17)
A new series of pyridine and pyrimidine derivatives is designed and synthesized as potential antitumor molecules. The tested compounds show promising in vitro cytotoxic activity against HL-60 cell line as eight compounds: 4, 6, 11, 13, 14, 15, 18 and
Wei Li et al.
Oncology letters, 9(4), 1719-1724 (2015-03-20)
Curcumin is an inexpensive, natural plant ingredient with protease inhibitor effects. The present study aimed to analyze the inhibitory effects of curcumin on the multiple myeloma (MM) RPMI 8226 cell line, and examine the underlying mechanism that promotes the apoptosis
Walaa Hamada Abd-Allah et al.
Drug development research, 80(7), 933-947 (2019-07-26)
Novel 1,1-disubstituted cyclohexane-1-carboxamides 6a-h, 7a-e, and 8a-b were designed and synthesized as apoptotic inducers. Cytotoxicity test revealed that some compounds have strong to moderate effect, while others displayed weak action against different cancer cell lines including, MCF-7, HepG2, A549, and
p53 at a glance.
Colleen A Brady et al.
Journal of cell science, 123(Pt 15), 2527-2532 (2010-10-14)
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