种属反应性
human
包装
kit of 96 wells (12 strips x 8 wells)
技术
ELISA: suitable
输入
sample type cell culture supernatant(s)
sample type plasma
sample type serum
assay range
inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 20 pg/mL
standard curve range: 24.58-6000 pg/mL
检测方法
colorimetric
运输
wet ice
储存温度
−20°C
基因信息
human ... PDCD1(5133)
一般描述
The antibody pair provided in this kit recognizes human Programmed Cell Death Protein 1.
应用
请参考Protocol了解详情。
生化/生理作用
Programmed cell death protein 1 (PDCD1) plays an important role in the immune regulation by acting as a negative co-stimulatory factor. It suppresses the functions and multiplication of T cells, thereby reducing the release of IL-2 (interleukin-2), IL-10 and IFN-γ (interferon γ). In the presence of tumor microenvironment, PDCD1 along with its ligand modulates T effector functioning, thereby protecting cancer cells from immune-associated rejection. Mutation in this gene is associated with symptoms and progression of multiple sclerosis and susceptibility to systemic lupus erythematosus.
其他说明
A sample Certificate of Analysis is available for this product.
Please type the word sample in the text box provided for lot number.
Please type the word sample in the text box provided for lot number.
警示用语：
Warning
危险声明
预防措施声明
危险分类
Met. Corr. 1
储存分类代码
8A - Combustible corrosive hazardous materials
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
Samane Mohammadzadeh et al.
Iranian journal of biotechnology, 17(4), e2104-e2104 (2020-07-17)
Programmed cell death protein-1 (PD-1)/PD-L1 pathway is one of the immune checkpoint pathways involved in the regulation of the immune responses and the suppression of anti-tumor defense. PD-1/PD-L1 blocking antibodies improve immune responses such as cytotoxic activity of CD8+/CD4+T cells
Kamila Hladíková et al.
Oral oncology, 82, 75-82 (2018-06-19)
Human papillomavirus (HPV) type 16 infection is one of the most important etiological agents of oropharyngeal squamous cell carcinoma. Patients with HPV-associated carcinomas of the head and neck were reported to have a better clinical outcome than patients with HPV-negative
Genevieve E Martin et al.
The Journal of infectious diseases, 221(7), 1135-1145 (2019-11-30)
Initiation of antiretroviral therapy (ART) in early compared with chronic human immunodeficiency virus (HIV) infection is associated with a smaller HIV reservoir. This longitudinal analysis of 60 individuals who began ART during primary HIV infection (PHI) investigates which pre- and
Bo Hu et al.
Scandinavian journal of immunology, 92(1), e12886-e12886 (2020-04-04)
This study aimed to investigate the effect of long non-coding RNA XLOC_003810 on the activation of CD4+ T cells and expression of PD-1/PD-L1 in patients with myasthenia gravis-related thymoma (MG-T). Thymus specimens and thymic mononuclear cells were obtained from MG
D Bommarito et al.
Clinical and experimental immunology, 188(3), 455-466 (2017-03-01)
The programmed cell death 1 (PD-1) receptor plays a major role in regulating T cell activation. Our aim was to determine how inflammation influences PD-1-mediated T cell suppression. Flow cytometry analysis of rheumatoid arthritis (RA) and psoriatic arthritis (PsA) synovial
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