RAB0780
小鼠Tyro3 /酪氨酸蛋白激酶受体TYRO3 ELISA试剂盒
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关于此项目
NACRES:
NA.32
UNSPSC Code:
41116158
Gene information:
mouse ... Tyro3(22174)
Input:
sample type cell culture supernatant(s)
sample type serum
sample type plasma
sample type serum
sample type plasma
Species reactivity:
mouse
Storage temp.:
−20°C
Shipped in:
wet ice
species reactivity
mouse
packaging
kit of 96 wells (12 strips x 8 wells)
technique(s)
ELISA: suitable
input
sample type cell culture supernatant(s)
sample type serum
sample type plasma
assay range
inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 0.4 ng/mL
standard curve range: 0.416-100 ng/mL
detection method
colorimetric
shipped in
wet ice
storage temp.
−20°C
Gene Information
mouse ... Tyro3(22174)
Application
请参考Protocol了解详情。
Biochem/physiol Actions
Tyrosine-protein kinase receptor (TYRO3) is a transmembrane tyrosine kinase receptor. It plays a significant role in the brain development during embryogenesis. It plays an important role in apoptotic cell clearance. In hepatocellular carcinoma, it is associated with tumor growth, aggressiveness and liver dysfunction. Mutations in the TYRO3 gene intronic regions are linked with asthma. TYRO3 is also a suppressor of type 2 immunity. As part of the TAM (TYRO3, AXL and MER receptors) family, it is activated by PROS1 (protein S) and GAS6 (growth arrest-specific gene 6). Changes in the expression of TYRO3 are linked with the proliferation and survival of cancer cells. Absence of TYRO3 in mice results in neurological disorders.
General description
The antibody pair provided in this kit recognizes mouse Tyro3.
signalword
Warning
hcodes
pcodes
Hazard Classifications
Met. Corr. 1
存储类别
8A - Combustible corrosive hazardous materials
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Receptor tyrosine kinases, TYRO3, AXL, and MER, demonstrate distinct patterns and complex regulation of ligand-induced activation.
Tsou WI
The Journal of Biological Chemistry, 289, 25750-25763 (2014)
Increased soluble phagocytic receptors sMer, sTyro3 and sAxl and reduced phagocytosis in juvenile-onset systemic lupus erythematosus.
Ballantine L, et al.
Pediatric Rheumatology Online Journal (2015)
Overexpression of Tyro3 and its implications on hepatocellular carcinoma progression.
Duan Y
International Journal of Oncology, 48, 358-366 (2016)
The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunity.
Chan PY
Science, 352, 99-103 (2016)
The Gas6/TAM System and Multiple Sclerosis.
Bellan M, et al.
International Journal of Molecular Sciences, 17 (2016)
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