species reactivity
mouse
packaging
kit of 96 wells (12 strips x 8 wells)
technique(s)
ELISA: suitable
input
sample type cell culture supernatant(s)
sample type serum
sample type plasma
assay range
inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 32 pg/mL
standard curve range: 32.77-8000 pg/mL
detection method
colorimetric
shipped in
wet ice
storage temp.
−20°C
Gene Information
mouse ... Lepr(16847)
Application
请参考Protocol了解详情。
Biochem/physiol Actions
Leptin receptor (Lepr) belonging to class I cytokine receptor family, binds with leptin, a small non-glycosylated peptide hormone and transduces signal. Lepr expression is present in brain and immune cells. Signal transduction through Lepr regulates fat metabolism in mammals. Lepr is part of the hematopoietic pathway. Lepr is a marker for mesenchymal stem/stromal cells (MSCs) and regulates the regenerative process of bone and cartilage after injury. Lepr regulates pancreatic β cell functions. Polymorphism in Lepr causes metabolic diseases like obesity, dyslipidemia, hypertension and Type 2 diabetes. Mutations in Lepr associates with polycystic ovarian syndrome (PCOS) susceptibility.
General description
The antibody pair provided in this kit recognizes mouse Leptin Receptor.
signalword
Warning
hcodes
pcodes
Hazard Classifications
Met. Corr. 1
存储类别
8A - Combustible corrosive hazardous materials
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
A role for leptin and its cognate receptor in hematopoiesis
Bennett BD, et al.
Current Biology, 6(9), 1170-1180 (1996)
LEPR gene polymorphism and plasma soluble leptin receptor levels are associated with polycystic ovary syndrome in Han Chinese women
Tu X, et al.
Personalized Medicine, 14(4), 299-307 (2017)
Leptin and leptin receptors in salivary glands of primary Sjogren?s syndrome
Erbasan F, et al.
Pathology Research and Practice, 212(11), 1010-1014 (2016)
Plasma soluble leptin receptor levels are associated with pancreatic beta-cell dysfunction in patients with type 2 diabetes
Morioka T, et al.
Journal of diabetes investigation, 9(1), 55-62 (2018)
Leptin receptor makes its mark on MSCs
Matsuzaki Y, et al.
Cell Stem Cell, 15(2), 112-114 (2014)
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