species reactivity
human
packaging
kit of 96 wells (12 strips x 8 wells)
technique(s)
ELISA: suitable
input
sample type plasma
sample type cell culture supernatant(s)
sample type serum sample(s)
assay range
inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 8 pg/ml
detection method
colorimetric
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... FGF21(26291)
Application
For research use only. Not for use in diagnostic procedures.
Please refer to the attached Protocolfor details.
Please refer to the attached Protocolfor details.
Biochem/physiol Actions
Fibroblast growth factor 21 (FGF-21) plays a vital role in the regulation of glucose uptake in mouse 3T3-L1 and primary human adipocytes. In addition, it is also implicated in lipid metabolism and in energy balance. FGF-21 plays a key role in controlling oxidative stress cell response. Overexpression of the gene has been associated with the development of acute pancreatitis, obesity, insulin resistance and metabolic syndrome. Additionally, elevated expression of FGF-21 has been observed in patients with insulin resistance and type 2 diabetes mellitus (T2DM). Thus, it can be considered as a potent target for an effective treatment of diabetes.
Other Notes
A sample Certificate of Analysis is available for this product. Please type the word sample in the text box provided for lot number.
signalword
Warning
hcodes
pcodes
Hazard Classifications
Met. Corr. 1
flash_point_f
Not applicable
flash_point_c
Not applicable
存储类别
10 - Combustible liquids
法规信息
新产品
此项目有
FGF-21 as a novel metabolic regulator
Kharitonenkov A, et al.
The Journal of Clinical Investigation, 1627-35 null
Fibroblast growth factor 21 and its novel association with oxidative stress.
Gomez-Samano M A, et al.
Redox Biology, 335-341 null
Circulating FGF-21 Levels in Normal Subjects and in Newly Diagnose Patients with Type 2 Diabetes Mellitus
Chen WW, et al.
Experimental and Clinical Endocrinology & Diabetes, 65-8 null