species reactivity
human
packaging
kit of 96 wells (12 strips x 8 wells)
technique(s)
ELISA: suitable
input
sample type serum sample(s)
sample type cell culture supernatant(s)
sample type plasma
assay range
inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 0.3 ng/ml
detection method
colorimetric
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... FGF23(8074)
General description
The FGF23 (fibroblast growth factor 23) gene is mapped to human chromosome 12p13.32 and encodes a phosphaturic hormone secreted by osteocytes. FGF23 is a 30 kDa protein and is part of the FGF19 subfamily.
This ELISA antibody pair detects Human FGF-23
Application
For research use only. Not for use in diagnostic procedures.
Please refer to the attached Protocolfor details.
Please refer to the attached Protocolfor details.
Biochem/physiol Actions
The protein fibroblast growth factor 23 (FGF23) mainly controls phosphate homeostasis and induces its excretion. Fgf23 maintains normal serum phosphate and calcium levels, by suppressing the action of sodium phosphate co-transporters and 25-hydroxyvitamin D 1-α-hydroxylase. Deficiency of the encoded protein causes chronic kidney disease. Leptin, a protein highly expressed in obesity is known influence the expression of this protein. Thus, higher FGF23 gene expression is observed in obese individuals. The FGF23 gene affects cardiac properties and is associated with cardiovascular risk factors such as alcoholism.
Other Notes
A sample Certificate of Analysis is available for this product. Please type the word sample in the text box provided for lot number.
signalword
Warning
hcodes
pcodes
Hazard Classifications
Met. Corr. 1
存储类别
8A - Combustible corrosive hazardous materials
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Fibroblast growth factor 23: state of the field and future directions.
Bhattacharyya N, et al.
Trends in Endocrinology and Metabolism, 23(12), 610-618 (2012)
The discovery of ?-Klotho and FGF23 unveiled new insight into calcium and phosphate homeostasis.
Nabeshima Y
Cellular and Molecular Life Sciences, 65(20), 3218-3218 (2008)
Alpha Klotho and fibroblast growth factor-23 among alcoholics.
Quintero-Platt G, et al.
Alcohol and Alcoholism (Oxford, Oxfordshire), 52(5), 542-549 (2017)
Fibroblast growth factor-23 is independently associated with cardiac mass in African-American adolescent males.
Falkner B, et al.
Journal of the American Society of Hypertension : JASH, 11(8), 480-487 (2017)
Cardiac Changes and Their Association with Fetuin-A and Fibroblast Growth Factor-23 in Children with Chronic Kidney Disease.
Mudi A, et al.
Nephron, 136(3), 233-242 (2017)
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