小鼠PAI-1 ELISA试剂盒

Name: 小鼠PAI-1 ELISA试剂盒
Brand: SIGMA

for cell culture supernatants, plasma, and serum samples

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关于此项目

NACRES:

NA.32

UNSPSC Code:

41116158

Species reactivity:

mouse, human

Storage temp.:

−20°C

Shipped in:

wet ice

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属性

species reactivity

mouse, human

technique(s)

ELISA: suitable

assay range

inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 80 pg/ml

shipped in

wet ice

storage temp.

−20°C

说明

General description

The PAI-1 (plasminogen activator inhibitor) gene is localized to human chromosome 7q22.1. Active form of PAI-1 is expressed in the blood and tissues. Platelets harbor both the active and latent forms of PAI-1.

This ELISA antibody pair detects mouse and human PAI-1.

Application

For research use only. Not for use in diagnostic procedures.
Please refer to the attached Protocolfor details.

Biochem/physiol Actions

PAI-1 (plasminogen activator inhibitor) produced by platelets takes part in stabilizing blood clotting mechanism. PAI-1 prevents plasminogen activation during fibrinolysis. This might lead to the risk of cardiovascular disease. Elevated levels of PAI-1 has been observed in type 2 diabetes mellitus and serves the reason for reduced insulin sensitivity. PAI-1 stimulates the process of cellular senescence. PAI-1 regulation occurs through p53 dependent TGF-β (transforming growth factor-β) signalling. Studies also also predict that stress and depression might influence PAI-1 expression.