RAB1320
人组织蛋白酶Z ELISA
for serum, plasma and cell culture supernatants
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关于此项目
UNSPSC Code:
12352200
Gene information:
human ... CTSZ(1522)
Input:
sample type serum
sample type plasma
sample type cell culture supernatant(s)
sample type plasma
sample type cell culture supernatant(s)
Species reactivity:
human
Storage temp.:
−20°C
Shipped in:
wet ice
species reactivity
human
technique(s)
ELISA: suitable
input
sample type serum
sample type plasma
sample type cell culture supernatant(s)
assay range
inter-assay cv: <12%
intra-assay cv: <10%
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... CTSZ(1522)
General description
Cathepsins are normally localized in lysosomes of almost all mammalian cells, but under certain conditions they can be secreted from the cells that take part in local proteolysis. Cathepsin Z is a cysteine protease, predominantly expressed in immune cells including monocytes, macrophages or dendritic cells.
This ELISA antibody pair detects Human Cathepsin Z (CTSZ/Cathepsin X/Cathepsin P)
Application
For research use only. Not for use in diagnostic procedures.
Please refer to the attached Protocolfor details.
Please refer to the attached Protocolfor details.
Biochem/physiol Actions
Cathepsins are lysosomal proteases that play an important role in the intracellular degradation of exogenous and endogenous proteins, activation of enzyme precursors, and tumor invasion and metastasis. Cathepsin Z is known to be associated with the pathogenesis of cancer and promotes the development and proliferation of tumor cells. Cathepsin Z mediates the process of proliferation, migration, maturation, adhesion, signal transduction and phagocytosis of immune cells.
Other Notes
A sample Certificate of Analysis is available for this product. Please type the word sample in the text box provided for lot number.
signalword
Warning
hcodes
pcodes
Hazard Classifications
Met. Corr. 1
存储类别
8A - Combustible corrosive hazardous materials
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Cysteine cathepsins B and X promote epithelial-mesenchymal transition of tumor cells.
Mitrovic A, et al.
European Journal of Cell Biology, 96(6), 622-631 (2017)
Localization and activity of various lysosomal proteases in Leishmania amazonensis-infected macrophages.
Prina E R I C, et al.
Infection and Immunity, 58(6), 1730-1737 (1990)
Dysregulation of apoptotic signaling pathways by interaction of RPLP0 and cathepsin X/Z in gastric cancer.
Teller A, et al.
Pathology Research and Practice, 211(1), 62-70 (2015)
Cysteine cathepsins and the cutting edge of cancer invasion.
Gocheva V and Joyce J A
Cell Cycle, 6(1), 60-64 (2007)
L Polgár et al.
The Journal of biological chemistry, 262(30), 14448-14453 (1987-10-25)
Negatively charged reactants are sensitive reactivity probes of the active site of cysteine proteases (Halász, P., and Polgár, L. (1977) Eur. J. Biochem. 79, 491-494). Thus, the thiolate-imidazolium ion pair of papain reacts at an enhanced rate with iodoacetate due
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