产品名称
人CD74 ELISA, for serum, plasma and cell culture supernatants
species reactivity
human
packaging
kit of 96 wells (12 strips x 8 wells)
technique(s)
ELISA: suitable
input
sample type plasma
sample type cell culture supernatant(s)
sample type serum
assay range
inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 0.1 ng/mL
standard curve range: 0.102-25 ng/mL
detection method
colorimetric
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... CD74(972)
Application
For research use only. Not for use in diagnostic procedures.
Please refer to the attached Protocolfor details.
Please refer to the attached Protocolfor details.
Biochem/physiol Actions
CD74 (HLA-DR (human leukocyte antigen – antigen D related) antigens-associated invariant chain) is part of major histocompatibility complex (MHC) class II and its function is associated with antigen presentation. Upregulation of the CD74 gene is observed cancer including breast cancer and it is known to promote to metastasis. CD74 also serves as a cytokine receptor in immune and epithelial cells. It induces cellular processes such as cell proliferation, migration and survival pathways.
General description
The CD74 (HLA-DR (human leukocyte antigen – antigen D related) antigens-associated invariant chain) gene encodes for a type II transmembrane protein and is expressed by antigen presenting cells such as monocytes, B cells, macrophages and dendritic cells. The CD74 gene is mapped to human chromosome 5q33.1.
Other Notes
A sample Certificate of Analysis is available for this product. Please type the word sample in the text box provided for lot number.
signalword
Warning
hcodes
pcodes
Hazard Classifications
Met. Corr. 1
存储类别
8A - Combustible corrosive hazardous materials
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Van?den Berghe?s 5q?syndrome in 2008.
Mohamedali A and Mufti G J
British Journal of Haematology, 144(2), 157-168 (2009)
CD74 and intratumoral immune response in breast cancer.
Wang Z Q, et al.
Oncotarget, 8(8), 12664-12664 (2017)
Gabriela Athziri Sánchez-Zuno et al.
Journal of clinical medicine, 11(1) (2022-01-12)
Macrophage migration inhibitory factor (MIF) significantly contributes to rheumatoid arthritis (RA) pathogenesis. We aimed to evaluate the canonical (CD74/CD44) and non-canonical MIF receptors (CXCR2,4 and 7) expression and sCD74 to establish their association with RA clinical activity according to DAS28-ESR.
GSK-3?-mediated fatty acid synthesis enhances epithelial to mesenchymal transition of TLR4-activated colorectal cancer cells through regulation of TAp63.
Park G B, et al.
International Journal of Oncology, 49(5), 2163-2172 (2016)
CD74 interacts with CD44 and enhances tumorigenesis and metastasis via RHOA-mediated cofilin phosphorylation in human breast cancer cells.
Liu Z, et al.
Oncotarget, 7(42), 68303-68303 (2016)
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