RAB1378
人CMG-2 ELISA
for serum, plasma and cell culture supernatants
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关于此项目
NACRES:
NA.32
UNSPSC Code:
41116158
Gene information:
human ... ANTXR2(118429)
Input:
sample type serum
sample type plasma
sample type cell culture supernatant(s)
sample type plasma
sample type cell culture supernatant(s)
Species reactivity:
human
Storage temp.:
−20°C
Shipped in:
wet ice
species reactivity
human
technique(s)
ELISA: suitable
input
sample type serum
sample type plasma
sample type cell culture supernatant(s)
assay range
inter-assay cv: <12%
intra-assay cv: <10%
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... ANTXR2(118429)
General description
Anthrax toxin receptor (ANTXR2), also known as capillary morphogenesis protein gene-2 (CMG2), is encoded by the gene mapped to human chromosome 24q21. CMG2 is a ubiquitously expressed type I transmembrane protein. It contains von Willebrand A (vWA) domain that is involved in binding lamin and collagen IV.
This ELISA antibody pair detects Human CMG-2. Other species not yet determined.
Application
For research use only. Not for use in diagnostic procedures.
Please refer to the attached Protocolfor details.
Please refer to the attached Protocolfor details.
Biochem/physiol Actions
Anthrax toxin receptor (ANTXR2)/ capillary morphogenesis protein gene-2 (CMG2) has been implicated in basement-membrane matrix assembly and endothelial cell morphogenesis. CMG2 acts as a chief receptor for anthrax in vivo. It stimulates the anthrax toxin activity by equipping toxin with a high-affinity binding anchor on the cell membrane and a path of entry into the host cell. Mutation in the gene is associated with the development of rare, autosomal recessive disorders called, Juvenile hyaline fibromatosis (JHF) and infantile systemic hyalinosis (ISH).
Other Notes
A sample Certificate of Analysis is available for this product. Please type the word sample in the text box provided for lot number.
signalword
Warning
hcodes
pcodes
Hazard Classifications
Met. Corr. 1
存储类别
8A - Combustible corrosive hazardous materials
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Systemic hyalinosis with heterozygous CMG2 mutations: a case report and review of literature.
Rahvar M, et al.
The American Journal of Dermatopathology, 38(5), e60-e63 (2016)
Roles of Anthrax Toxin Receptor 2 in Anthrax Toxin Membrane Insertion and Pore Formation
Sun J, et al.
Toxins, 8(2), 34-34 (2016)
Identification of 2 Novel ANTXR2 Mutations in Patients With Hyaline Fibromatosis Syndrome and Proposal of a Modified Grading System
Denadai R, et al.
American Journal of Medical Genetics. Part A, 158(4), 732-742 (2012)
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