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安全信息

RAB1476

Sigma-Aldrich

人GAPHD ELISA

for serum, plasma and cell culture supernatants

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NACRES:
NA.32

种属反应性

human

包装

kit of 96 wells (12 strips x 8 wells)

技术

ELISA: suitable

输入

sample type cell culture supernatant(s)
sample type serum
sample type plasma

assay range

inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 0.82 ng/mL
standard curve range: 0.819-200 ng/mL

检测方法

colorimetric

运输

wet ice

储存温度

−20°C

基因信息

human ... GAPDH(2597)

相关类别

一般描述

The GAPHD (glyceraldehyde-3-phosphate dehydrogenase) gene is mapped to human chromosome 12p13.31. GAPHD encodes a multifunctional protein which is a glycolytic enzyme.
This ELISA antibody pair detects human GAPHD. Other species not yet determined.

应用

For research use only. Not for use in diagnostic procedures.
Please refer to the attached Protocolfor details.

生化/生理作用

GAPHD (glyceraldehyde-3-phosphate dehydrogenase) is associated with the progression of Huntington′s disease by increasing cytotoxicity. Gaphd is often referred to as glycolytic enzyme and catalyzes the sixth step in glycolysis. The Gaphd enzyme possess uracil-DNA glycosylase activity. The enzyme regulates transcription, posttranscriptional gene expression, intracellular membrane trafficking and apoptosis.

其他说明

A sample Certificate of Analysis is available for this product. Please type the word sample in the text box provided for lot number.

象形图

Corrosion
GHS05

警示用语：

Warning

危险声明

H290

预防措施声明

P234 - P390

危险分类

Met. Corr. 1

储存分类代码

8A - Combustible, corrosive hazardous materials

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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索取COA

A hydrocortisone derivative binds to GAPDH and reduces the toxicity of extracellular polyglutamine-containing aggregates.
Lazarev V F, et al.
Biochemical and Biophysical Research Communications, 487(3), 723-727 (2017)
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) aggregation causes mitochondrial dysfunction during oxidative stress-induced cell death.
Nakajima H, et al.
The Journal of Biological Chemistry (2017)
Prediction of potential cancer-risk regions based on transcriptome data: towards a comprehensive view.
Alisoltani A, et al.
PLoS ONE, 9(5), e96320-e96320 (2014)
Role of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) in DNA repair
Kosova A A, et al.
Biochemistry (Moscow), 82(6), 643-654 (2017)

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