S0149
链球菌溶血素O 来源于化脓链球菌
From Streptococcus pyogenes, Thiol-activated toxin, lyophilized powder
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Form:
lyophilized powder
产品名称
链球菌溶血素O 来源于化脓链球菌, γ-irradiated
biological source
Streptococcus pyogenes
Quality Segment
sterility
γ-irradiated
form
lyophilized powder
application(s)
cell analysis
storage temp.
2-8°C
Gene Information
Streptococcus pyogenes ... slo(900490)
Application
Streptolysin O from Streptococcus pyogenes has been used in streptolysin O (SLO) permeabilization. It has also been used to evaluate the barrier integrity and cytotoxicity of caco-2 and T84 IEC polarized monolayers.
透膜允许细胞摄取大分子或带电分子。
Biochem/physiol Actions
Streptolysin O (SLO), obtained from Streptococcus pyogenes has the capability to block osteoclastogenesis, induced by receptor activator of nuclear factor κ-Β ligand (RANK) through the NF-κB signaling pathway. Streptococcus pyogenes (GAS) is a bacterial strain that results in bacterial arthritis, osteomyelitis and implant infections.
能穿透动物细胞膜的巯基活化毒素。
能穿透动物细胞膜的巯基活化毒素。该蛋白作为单体与膜胆固醇结合，随后聚合成围绕>12 nm孔的大弧形和环形结构。
Preparation Note
Prepared from S 5265
Other Notes
One unit will cause 50% lysis of 2% red blood cell suspensions in phosphate buffered saline, pH 7.4, after incubation at 37 °C for 30 min.
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 1 Dermal - Acute Tox. 1 Inhalation - Acute Tox. 1 Oral
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)