S0191
Sonic Hedgehog Peptide from mouse
≥97% (SDS-PAGE), recombinant, expressed in E. coli, Fused to a histidine tag at the C-terminus, lyophilized powder
别名:
Shh
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关于此项目
biological source
mouse
Quality Segment
recombinant
expressed in E. coli
assay
≥97% (SDS-PAGE)
form
lyophilized powder
potency
0.4-3.0 μg/mL ED50
mol wt
predicted mol wt 20 kDa
packaging
pkg of 25 μg
storage condition
avoid repeated freeze/thaw cycles
impurities
<1 EU/μg
UniProt accession no.
storage temp.
−20°C
Gene Information
mouse ... Shh(20423)
General description
Sonic hedgehog (Shh) is a morphogenic glycoprotein. The gene encoding it is localized on mouse chromosome 5.
Application
Sonic hedgehog peptide from mouse has been used for neural differentiation.
Biochem/physiol Actions
Sonic hedgehog (Shh) has a role in fracture healing and regeneration. The protein associates with its receptor Patched (Ptc-1), de-represses Smoothened (Smo) and activates the Gli family of transcription factors. Mutations in the Shh pathway have been linked to developmental diseases and cancer.
Cell signaling peptide involved in embryonic morphogenic development of several tissues including Hensen′s node, the notochord, and the neural tube.
Involved in embryonic morphogenic development of several tissues including Hensen′s node, the notochord, and the neural tube.
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline, pH 7.4, containing 5% trehalose and 50 μg of bovine serum albumin per 1 μg of cytokine.
Other Notes
N-terminal peptide encoding amino acid residues 25-198.
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable