SMILES string
O3[C@H]([C@@H]([C@H]([C@@H]([C@H]3CO)O)O)O)O.O(C)c1c(ccc(c1)C[C@H]([C@H](CO)Cc2cc(c(cc2)O)OC)CO)O
InChI
1S/C20H26O6.C6H12O6/c1-25-19-9-13(3-5-17(19)23)7-15(11-21)16(12-22)8-14-4-6-18(24)20(10-14)26-2;7-1-2-3(8)4(9)5(10)6(11)12-2/h3-6,9-10,15-16,21-24H,7-8,11-12H2,1-2H3;2-11H,1H2/t15-,16-;2-,3-,4+,5-,6-/m01/s1
InChI key
MJYQFWSXKFLTAY-OVEQLNGDSA-N
assay
≥97% (HPLC)
form
powder
storage condition
protect from light
color
white to off-white
solubility
H2O: 1 mg/mL, clear, colorless
application(s)
metabolomics
vitamins, nutraceuticals, and natural products
storage temp.
2-8°C
Quality Level
General description
亚麻木酚素（SDG）是亚麻籽中的一种必需的膳食木脂素。它具有寡聚体结构。
Application
- 补充蔗糖、亚麻籽油或两者同时补充的亚麻籽粉：对奶牛牛奶肠内酯、瘤胃微生物群谱、生产性能和营养利用的影响。：本研究探讨了亚麻籽粉中亚麻木酚素（SDG）对奶牛产奶量、肠内酯水平和瘤胃微生物群的影响，强调了其在提高营养利用率和生产性能方面的作用（Ghedini CP et al., 2024）。
- 一名合并胰腺癌和肾癌患者单独接受亚麻木酚素治疗的成功结果：病例报告。：该病例报告记录了一名仅接受SDG治疗的胰腺癌和肾癌患者，展示了其在肿瘤学中的潜在治疗效果，并强调了在癌症治疗中的新应用（Wu H et al., 2024）。
- 利格列汀和亚麻木酚素通过抑制高同型半胱氨酸血症诱导的内质网应激，减轻高蛋氨酸饮食诱导的大鼠高脂血症和心脏肥厚。：本研究证明了SDG和利格列汀在缓解高脂血症和心脏肥厚方面的联合治疗作用，突出了其在心血管健康应用中的潜力（Jalal IA et al., 2023）。
Biochem/physiol Actions
亚麻木酚素（SDG）是一种金属螯合配体，对乳腺癌细胞有抗增殖和促凋亡作用。它对镉诱导的大鼠肾毒性具有肾脏保护作用。SDG 是一种强效抗炎剂，可防止血脑屏障与炎症细胞的相互作用，并预防神经炎性疾病。它还是一种良好的抗糖尿病剂。
开环异落叶松树脂酚二葡萄糖苷是存在于亚麻、向日葵、芝麻和南瓜种子中的一种植物化学物质。它是哺乳动物木脂素和植物雌激素的一种前体。开环异落叶松树脂酚二葡萄糖苷已被证明具有抗氧化和心脏保护作用。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Márcia Constantino Colli et al.
Journal of medicinal food, 15(9), 840-845 (2012-08-29)
The objective of this study was to evaluate the efficacy of flaxseed meal and flaxseed extract in reducing climacteric symptoms of menopausal women. Ninety menopausal women were randomly distributed into three study groups: group I received 1 g per day of
Thomas J Schmidt et al.
Phytochemistry, 82, 89-99 (2012-08-03)
Mature seeds of 20 Linum species were analyzed for their content of lignans. The seeds of common flax (Linum usitatissimum L.) are known to contain as characteristic lignan sesoisolariciresinol diglucoside (SDG), whose presence in seeds of some other Linum species
Xian-wei Li et al.
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 35(2), 248-253 (2012-07-25)
To study the influence of Secoisolariciresinol Diglucoside (SDG) combined with Bortezomib on induction of apoptosis in lung cancer cell line A549 and its relative mechanisms. The effect on proliferation was evaluated by MTT assay. The cell apoptosis was studied by
Parfait Kezimana et al.
Frontiers in genetics, 9, 641-641 (2019-01-09)
Secoisolariciresinol diglucoside (SDG), found mainly in flaxseed, is one of the essential lignans. SDG, as well as the beneficial fatty acid composition and high fiber content, has made flaxseed an important source of functional food or nutraceutical ingredients. Various studies
Melpo Christofidou-Solomidou et al.
Radiation research, 178(6), 568-580 (2012-10-31)
While dietary wholegrain Flaxseed (FS) has potent anti-inflammatory, anti-fibrotic and antioxidant properties in murine models of acute and chronic lung injury, the main bioactive ingredient that contributes to these protective effects remains unknown. This study evaluated the lignan complex of
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