S0383
磺胺对甲氧嘧啶
别名:
5-甲氧基磺胺嘧啶, N1-(5-甲氧基嘧啶-2-基)磺胺
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关于此项目
经验公式（希尔记法）:
C11H12N4O3S
化学文摘社编号:
分子量:
280.30
UNSPSC Code:
51283913
NACRES:
NA.85
PubChem Substance ID:
EC Number:
211-480-8
Beilstein/REAXYS Number:
621130
MDL number:
InChI key
GPTONYMQFTZPKC-UHFFFAOYSA-N
InChI
1S/C11H12N4O3S/c1-18-9-6-13-11(14-7-9)15-19(16,17)10-4-2-8(12)3-5-10/h2-7H,12H2,1H3,(H,13,14,15)
SMILES string
COc1cnc(NS(=O)(=O)c2ccc(N)cc2)nc1
form
powder
storage condition
(Keep container tightly closed in a dry and well-ventilated place. Light sensitive.)
color
white to faint yellow
antibiotic activity spectrum
Gram-negative bacteria
Gram-positive bacteria
mycobacteria
parasites
mode of action
enzyme | inhibits
storage temp.
2-8°C
Quality Level
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Application
Sulfameter is a sulfonamide antibiotic used as a leprostatic agent and to treat urinary tract infections. It has been investigated as a potential therapy for chloroquine-resistant malaria during pregnancy.
Biochem/physiol Actions
Sulfameter is a sulfonamide antibiotic. Sulfonamides block the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfonamides are competitive inhibitors of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid. Sulfameter is a dihydrofolate reductase (DHFR) inhibitor. Sulfonamides are active against Gram positive bacteria and Gram negative bacteria. Mode of resistance is via the alteration of dihydropteroate synthase or alternative pathway for folic acid synthesis.
General description
Chemical structure: sulfonamide
Other Notes
Keep container tightly closed in a dry and well-ventilated place. Light sensitive.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
M Forland et al.
Diabetes care, 8(5), 499-506 (1985-09-01)
Forty-five women with diabetes mellitus and urinary tract infections have been followed an average of 34 mo on treatment protocols based on localization of infection as determined by the presence or absence of antibody-coated bacteria (ACB). Treatment was usually, but
Treatment of Chloroquine-Resistant Malaria During Pregnancy
Elliott K. Main, Denise M. Main, et al.
Journal of the American Medical Association, 249, 3207-3209 (1983)
Identification of polymorphs of sulfamethoxydiazine by optical and morphological methods.
T Yokoyama et al.
Chemical & pharmaceutical bulletin, 26(4), 1044-1048 (1978-04-01)
H Coradello et al.
Wiener klinische Wochenschrift, 93(3), 93-96 (1981-02-06)
Two newborn infants with congenital toxoplasmosis despite serological testing during pregnancy were observed at our premature and neonatal intensive care unit within a short time of one another. In one case the counter-regulatory late first test, performed only in the
E K Main et al.
JAMA, 249(23), 3207-3209 (1983-06-17)
A pregnant 36-year-old Vietnamese refugee with chloroquine-resistant Plasmodium falciparum infection was treated with pyrimethamine and a sulfonamide. This treatment produced rapid clearance of the patient's parasitemia and was associated with a resumption of normal fetal and uterine growth. Because the
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