S0445
Anti-Serotonin 5-HT2B Receptor antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
别名:
Anti-5-HT(2B), Anti-5-HT-2B, Anti-5-HT2B
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关于此项目
UNSPSC Code:
12352203
MDL number:
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IHC (p)
Citations:
4
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human
availability
not available in Japan
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 4-6 μg/mL using human brain, neurons and glia
UniProt accession no.
shipped in
wet ice
storage temp.
−70°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... HTR2B(3357)
mouse ... Htr2b(15559)
rat ... Htr2b(29581)
General description
Multiplbe genes encode different subtypes of serotonin (5HT) receptor and are species specific. HTR2B is expressed in mammalian brain and is localized to GABA (γ-aminobutyric acid) producing neurons of dorsal hypothalamic nucleus. The HTR2B gene is mapped to human chromosome 2q37.1.
The Serotonin 5-HT2B Receptor regulates cardiomyocyte development and growth. Activation of 5-HT2B receptors may also contribute to initiation of sleep and to theta generation during W and PS under physiological conditions.
Immunogen
synthetic peptide corresponding to the second extracellular loop of human serotonin 5-HT2B receptor, conjugated KLH. The immunizing peptide has 80% homology with the rat gene and 93% homology with the mouse gene.
Biochem/physiol Actions
The functions of serotonin (5HT) receptors are associated with sleep disorders, anxiety, depression and schizophrenia.
Physical form
solution in phosphate buffered saline containing ≤0.1% sodium azide
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Multiple serotonin receptor subtypes: molecular cloning and functional expression.
Teitler M and Herrick-Davis K
Critical Reviews in Neurobiology, 8(3), 175-188 (1994)
Increased wakefulness, motor activity and decreased theta activity after blockade of the 5-HT2B receptor by the subtype-selective antagonist SB-215505.
Kantor S, et al.
British Journal of Pharmacology, 142(8), 1332-1342 (2004)
Serotonin receptors and their function in sleep, anxiety disorders and depression.
Leonard B E, et al.
Psychotherapy and Psychosomatics, 65(2), 66-75 (1996)
Prenatal diagnosis of microdeletion 16p13.11 combination with partial monosomy of 2q37.1-qter and partial trisomy of 7p15.3-pter in a fetus with bilateral ventriculomegaly, agenesis of corpus callosum, and polydactyly.
Sung P L, et al.
Taiwanese Journal of Obstetrics & Gynecology, 51(2), 260-265 (2012)
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