S0447
SIS3
≥98% (HPLC), TGF-β1/ALK-5 phosphorylation inhibitor, powder
别名:
(2E)-1-(6,7-二甲氧基-3,4-二氢-1H-异喹啉-2-基)-3-(1-甲基-2-苯基-1H-吡咯并[2,3-b]吡啶吡啶-3-基)-丙烯酮 盐酸盐
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关于此项目
经验公式(希尔记法):
C28H27N3O3 · HCl
化学文摘社编号:
分子量:
489.99
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
产品名称
SIS3, ≥98% (HPLC), powder
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
yellow
溶解性
H2O: <2 mg/mL
DMSO: >20 mg/mL
储存温度
2-8°C
SMILES字符串
Cl.COc1cc2CCN(Cc2cc1OC)C(=O)\C=C\c3c(-c4ccccc4)n(C)c5ncccc35
InChI
1S/C28H27N3O3.ClH/c1-30-27(19-8-5-4-6-9-19)22(23-10-7-14-29-28(23)30)11-12-26(32)31-15-13-20-16-24(33-2)25(34-3)17-21(20)18-31;/h4-12,14,16-17H,13,15,18H2,1-3H3;1H/b12-11+;
InChI key
CDKIEBFIMCSCBB-CALJPSDSSA-N
应用
Sugar insensitive 3 (SIS3) 已被用作各种细胞中的samd3抑制剂。
生化/生理作用
SIS3 是一种 TGF-β1/ALK-5磷酸化 Smad3 的新型特异性抑制剂
Sugar insensitive 3 (SIS3) 促进药物引起的细胞凋亡,并阻碍三磷酸腺苷(ATP)结合盒(ABC)转运蛋白 (ABCB1) 和ABCG2发挥功能。它使在癌细胞中过度表达的ABCB1 和 ABCG2再次敏化,这有助于化疗。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Qinghui Zhang et al.
Cancer science, 110(8), 2507-2519 (2019-06-20)
Abnormal tumor microenvironment and the epithelial-mesenchymal transition (EMT) are important features of tumor metastasis. However, it remains unknown how signals can form complicated networks to regulate the sustainability of the EMT process. The aim of our study is to explore
The proto-oncogene tyrosine protein kinase Src is essential for macrophage-myofibroblast transition during renal scarring
Tang PMK, et al.
Kidney International, 93(1), 173-187 (2018)
Jae-Min Shin et al.
American journal of rhinology & allergy, 30(6), 385-390 (2017-01-27)
It is well known that doxycycline has antibacterial and anti-inflammatory effects. In this study, we aimed to investigate the effects of doxycycline on the transforming growth factor (TGF) beta 1-induced matrix metalloproteinase (MMP) 2 expression, migration, and collagen contraction, and
SIS3, a specific inhibitor of Smad3 reverses ABCB1-and ABCG2-mediated multidrug resistance in cancer cell lines
Wu CP, et al.
Cancer letters, 433, 259-272 (2018)
Karl David Brown et al.
Investigative ophthalmology & visual science, 58(7), 3011-3017 (2017-06-13)
Fibrotic scarring after ocular surgeries and chemical burn injuries can impede clarity of the cornea and cause vision impairment. Transforming growth factor β (TGFβ) signaling pathway is known to mediate fibrotic scarring, and NADPH oxidase-derived reactive oxygen species has been
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