S0501
硝普钠 二水合物
别名:
SNP, 五氰基亚硝酰基铁酸钠, 亚硝基铁氰化钠, 硝普酸钠
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关于此项目
线性分子式:
Na2[Fe(CN)5NO] · 2H2O
化学文摘社编号:
分子量:
297.95
EC Number:
238-373-9
UNSPSC Code:
12352300
MDL number:
InChI key
OIRZWVYIQXBRFC-UHFFFAOYSA-N
InChI
1S/5CN.Fe.NO.2Na.2H2O/c5*1-2;;1-2;;;;/h;;;;;;;;;2*1H2/q;;;;;2*-1;2*+1;;
SMILES string
O.O.[Na+].[Na+].O=N[Fe--](C#N)(C#N)(C#N)(C#N)C#N
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Biochem/physiol Actions
体内释放 NO，从而活化鸟苷酸环化酶、ADP-核糖基转移酶和环氧合酶并抑制脂肪氧合酶。诱导血管舒张以及抑制血小板聚集。
Other Notes
This product has been replaced by 228710-Sigma-Aldrich | Sodium nitroferricyanide(III) dihydrate, ACS reagent, 99% | Na2[Fe(CN)5NO]
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
法规信息
新产品
此项目有
B Brüne et al.
The Journal of biological chemistry, 264(15), 8455-8458 (1989-05-25)
Sodium nitroprusside is a vasodilator and an inhibitor of platelet activation. It is thought that these effects are mediated by the spontaneous release of nitric oxide and stimulation of cytosolic guanylate cyclase. We have found that sodium nitroprusside (5-200 microM)
C M Roos et al.
Journal of applied physiology (Bethesda, Md. : 1985), 77(1), 51-57 (1994-07-01)
We localized the sites of vasodilation of inhaled nitric oxide (NO), a selective pulmonary vasodilator, and sodium nitroprusside (SNP) in isolated rat lungs. The sites were determined by analyzing the arterial, venous, and double-occlusion data with a two-resistor (small arteries
F J Azula et al.
Molecular pharmacology, 50(2), 367-379 (1996-08-01)
Different drugs that elevate the cGMP levels inhibit the agonist-induced platelet activation. The mechanisms of action of cGMP probably include inhibition of both phospholipase C and the increase in intracellular Ca2+ concentration, and these effects seem to be mediated by
Feelisch, M.
Journal of Cardiovascular Pharmacology, 17, S25-S25 (1991)
M Maccarrone et al.
Biochemical and biophysical research communications, 219(1), 128-133 (1996-02-06)
The nitric oxide (N0-releasing agents sodium nitroprusside (SNP) and S-nitroso-N-acetylpenicillamine (SNAP) inhibit dioxygenase activity of lipoxygenase in human platelets and human CHP100 neuroblastoma cells, leading the latter to necrosis. The effect of both NO-donors on the dioxygenase reaction was investigated
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