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S0532

番木鳖碱

Name: 番木鳖碱
Brand: SIGMA

Glycine receptor antagonist

别名:

(-)-番木鳖碱

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关于此项目

经验公式（希尔记法）:

C₂₁H₂₂N₂O₂

化学文摘社编号:

57-24-9

分子量:

334.41

NACRES:

NA.54

PubChem Substance ID:

24899441

UNSPSC Code:

12352210

EC Number:

200-319-7

MDL number:

MFCD00005941

Beilstein/REAXYS Number:

52979

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属性

产品名称

番木鳖碱,

Quality Segment

200

mp

284-286 °C (lit.)

solubility

chloroform: soluble, clear to hazy

SMILES string

[H][C@@]12CC(=O)N3c4ccccc4[C@]56CC[N@H]7CC(=CCO1)[C@]([H])(C[C@@H]57)[C@]2([H])[C@]36[H]

InChI

1S/C21H22N2O2/c24-18-10-16-19-13-9-17-21(6-7-22(17)11-12(13)5-8-25-16)14-3-1-2-4-15(14)23(18)20(19)21/h1-5,13,16-17,19-20H,6-11H2/t13-,16-,17-,19-,20-,21+/m0/s1

InChI key

QMGVPVSNSZLJIA-FVWCLLPLSA-N

说明

General description

Strychnine is a colorless, odourless and bitter tasting powder. It is absorbed in skin, gastrointestinaland respiratory tract. Strychnine generates oxides of nitrogen and carbon on decomposition.

Strychnine is a glycine receptor antagonist not associated with the N-methyl-D-aspartate (NMDA) receptor. It is an alkaloid extracted from Strychnos nux vomica seeds.

Application

Strychnine has been used as a glycine receptors antagonist in hippocampal CA1 pyramidal and rostral ventromedial medulla (RVM) neurons. It has also been used as type C glycine receptor antagonist in direction selective (DS) retinal cells.

Strychnine has been used in antagonist profiling to characterize a novel nicotinic receptor in Aplysia neuroendocrine cells.

Biochem/physiol Actions

At low doses, strychnine is used for circulatory problems, gastrointestinal disorders and eye diseases.

Strychnine is used as a rodenticide and a glycine receptor antagonist, which inhibits Renshaw cell-motor neuron synapse. It binds to the α subunit N-terminal region of the glycine receptor. The effect of strychnine is neutralized in the presence of glycine receptor agonist ivermectin. Strychnine also inhibits leukocyte motility.

惊厥剂；与 NMDA 受体无关的甘氨酸受体拮抗剂。