S0693
SB 204741
>98% (HPLC)
别名:
N-（1-甲基-1H-5-吲哚基）-N′-（3-甲基-5-异噻唑基）脲
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关于此项目
经验公式（希尔记法）:
C14H14N4OS
化学文摘社编号:
分子量:
286.35
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
产品名称
SB 204741, >98% (HPLC)
InChI key
USFUFHFQWXDVMH-UHFFFAOYSA-N
SMILES string
Cc1cc(NC(=O)Nc2ccc3n(C)ccc3c2)sn1
InChI
1S/C14H14N4OS/c1-9-7-13(20-17-9)16-14(19)15-11-3-4-12-10(8-11)5-6-18(12)2/h3-8H,1-2H3,(H2,15,16,19)
assay
>98% (HPLC)
form
solid
color
off-white to tan
solubility
DMSO: soluble >20 mg/mL
originator
GlaxoSmithKline
storage temp.
2-8°C
Quality Level
Gene Information
human ... DRD2(1813), DRD3(1814), DRD5(1816), HTR1E(3354), HTR2A(3356), HTR2B(3357), HTR2C(3358)
rat ... Adra1a(29412), Gabra2(29706), Htr1a(24473), Htr2b(29581), Htr3a(79246)
Application
SB 204741已被用作5-羟色胺受体2B（Htr2B）拮抗剂：
- 抑制Htr2b信号传导以测定其在三个月大的成年斑马鱼中肝星状细胞（HSC）活化的作用
- 在小鼠抑郁样行为研究中测试其对氟西汀效果的抑制作用
- 在小鼠中测试其减少舍曲林引起的抓挠行为的作用
Biochem/physiol Actions
5-HT2B血清素受体拮抗剂。
SB 204741 减少脊柱C-纤维突触中低剂量丁丙诺啡引起的突触易化（synaptic facilitation）。
Features and Benefits
该化合物由 GlaxoSmithKline开发。想浏览其他制药公司开发的化合物和已批准药物/候选药物目录， 请单击此处。
Legal Information
根据GlaxoSmithKline的协议出售用于研究目的
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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