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Merck
CN

S0885

生长抑素

powder, γ-irradiated, BioXtra, suitable for cell culture

别名:

SRIF, 促生长素释放抑制因子, 生长抑素-14, 生长激素释放抑制因子

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关于此项目

经验公式（希尔记法）:
C76H104N18O19S2
化学文摘社编号:
38916-34-6
分子量:
1637.88
UNSPSC Code:
12352209
NACRES:
NA.77
PubChem Substance ID:
24899450
EC Number:
254-186-5
Beilstein/REAXYS Number:
6436064
MDL number:
MFCD00076762
Biological source:
synthetic (organic)
Form:
powder
Assay:
≥50%

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InChI key

NHXLMOGPVYXJNR-FQSIDJEASA-N

InChI

1S/C76H104N18O19S2/c1-41(79)64(100)82-37-61(99)83-58-39-114-115-40-59(76(112)113)92-72(108)57(38-95)91-75(111)63(43(3)97)94-71(107)54(33-46-23-11-6-12-24-46)90-74(110)62(42(2)96)93-66(102)51(28-16-18-30-78)84-69(105)55(34-47-36-81-49-26-14-13-25-48(47)49)88-68(104)53(32-45-21-9-5-10-22-45)86-67(103)52(31-44-19-7-4-8-20-44)87-70(106)56(35-60(80)98)89-65(101)50(85-73(58)109)27-15-17-29-77/h4-14,19-26,36,41-43,50-59,62-63,81,95-97H,15-18,27-35,37-40,77-79H2,1-3H3,(H2,80,98)(H,82,100)(H,83,99)(H,84,105)(H,85,109)(H,86,103)(H,87,106)(H,88,104)(H,89,101)(H,90,110)(H,91,111)(H,92,108)(H,93,102)(H,94,107)(H,112,113)/t41-,42+,43+,50-,51-,52-,53-,54-,55-,56-,57?,58-,59-,62-,63-/m0/s1

SMILES string

[H]N1[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@@H](Cc4c[nH]c5ccccc45)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc6ccccc6)C(=O)N[C@@H]([C@@H](C)O)C(=O)NC(CO)C(=O)N[C@@H](CSSC[C@H](NC(=O)CNC(=O)[C@H](C)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C1=O)C(O)=O

biological source

synthetic (organic)

sterility

γ-irradiated

product line

BioXtra

assay

≥50%

form

powder

potency

0.3-50 ng/mL

concentration

≥50% (HPLC)

technique(s)

cell culture | mammalian: suitable

solubility

cell culture medium: 10 mL/vial

shipped in

ambient

storage temp.

−20°C

Quality Level

200

Gene Information

human ... SSTR1(6751), SSTR2(6752), SSTR3(6753), SSTR4(6754), SSTR5(6755)

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Biochem/physiol Actions

Somatostatin regulates endocrine function and cell proliferation via interaction with G-protein-coupled somatostatin receptors. It exists in two active forms produced by alternative cleavage of a single preproprotein (14 aa and 28 aa forms). Somatosatin inhibits the release of growth hormone; thyroid-stimulating hormone and a range of gastrointestinal hormones: Cholecystokinin (CCK); Enteroglucagon; Gastrin; Gastric inhibitory polypeptide (GIP); Motilin; Secretin; Vasoactive intestinal peptide (VIP).

Physical form

0°C 下为粉末状；分成小份冻存，以避免使用时重复冰冻/解冻

Preparation Note

加入 10mL 无菌培养基可制成 2μg/mL 的储存液。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
SLBZ9150
SLBT1708
SLBK6825V
109K8737
039K8731

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Henrik H Hansen et al.
The Journal of pharmacology and experimental therapeutics, 350(3), 657-664 (2014-07-06)
Type 2 diabetes is characterized by impaired β-cell function associated with progressive reduction of insulin secretion and β-cell mass. Evidently, there is an unmet need for treatments with greater sustainability in β-cell protection and antidiabetic efficacy. Through an insulin and
Zaki Alsahafi et al.
The Journal of physiology, 593(16), 3673-3692 (2015-05-27)
This study investigates the effects on ventilation of an excitatory stimulus delivered in a spatially and temporally precise manner to the inspiratory oscillator, the preBötzinger complex (preBötC). We used an adeno-associated virus expressing channelrhodopsin driven by the synapsin promoter to
Amelie Soumier et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 39(9), 2252-2262 (2014-04-03)
Reduced expression of somatostatin (SST) is reported across chronic brain conditions including major depression and normal aging. SST is a signaling neuropeptide and marker of gamma-amino butyric acid (GABA) neurons, which specifically inhibit pyramidal neuron dendrites. Studies in auditory cortex
Yuko Takano et al.
PloS one, 10(7), e0133812-e0133812 (2015-07-21)
Animal models with defective glucagon action show hyperplasia of islet α-cells, however, the regulatory mechanisms underlying the proliferation of islet endocrine cells remain largely to be elucidated. The Gcggfp/gfp mice, which are homozygous for glucagon/green fluorescent protein knock-in allele (GCGKO)
M Hadi Saiepour et al.
Current biology : CB, 25(6), 713-721 (2015-03-11)
To ensure that neuronal networks function in a stable fashion, neurons receive balanced inhibitory and excitatory inputs. In various brain regions, this balance has been found to change temporarily during plasticity. Whether changes in inhibition have an instructive or permissive
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