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S1014

Streptonigrin

Name: Streptonigrin
Brand: SIGMA

from Streptomyces flocculus, ≥98% (HPLC), powder, apoptosis inducer

别名:

Bruneomycin, Nigrin

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关于此项目

经验公式（希尔记法）:

C₂₅H₂₂N₄O₈

化学文摘社编号:

3930-19-6

分子量:

506.46

NACRES:

NA.77

PubChem Substance ID:

24899458

UNSPSC Code:

12352200

EC Number:

223-501-8

MDL number:

MFCD00063401

Beilstein/REAXYS Number:

599390

Assay:

≥98%

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属性

产品名称

链黑霉素来源于柔毛链霉菌, ≥98%

Quality Segment

200

assay

≥98%

antibiotic activity spectrum

viruses

mode of action

DNA synthesis | interferes

storage temp.

2-8°C

SMILES string

COc1ccc(c(O)c1OC)-c2c(C)c(nc(c2N)-c3ccc4C(=O)C(OC)=C(N)C(=O)c4n3)C(O)=O

InChI

1S/C25H22N4O8/c1-9-14(10-6-8-13(35-2)23(36-3)20(10)30)15(26)19(29-17(9)25(33)34)12-7-5-11-18(28-12)22(32)16(27)24(37-4)21(11)31/h5-8,30H,26-27H2,1-4H3,(H,33,34)

InChI key

PVYJZLYGTZKPJE-UHFFFAOYSA-N

说明

Biochem/physiol Actions

Streptonigrin (SN) is an aminoquinone antitumour antibiotic. Its antineoplastic activity requires reductive activation by Xanthine-converting enzymes. It induces apoptosis by a mechanism involving NF-κB. DNA cleavage reaction and chromosome damage by SN are influenced by the nature of the metal ion present and dependent on the production of free radicals. Its antibiotic activity is iron-activated.

pictograms

GHS06

signalword

Danger

hcodes

H300

pcodes

P264 - P270 - P301 + P310 - P405 - P501

Hazard Classifications

Acute Tox. 1 Oral

存储类别

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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