S1014
Streptonigrin
from Streptomyces flocculus, ≥98% (HPLC), powder, apoptosis inducer
别名:
Bruneomycin, Nigrin
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关于此项目
经验公式（希尔记法）:
C25H22N4O8
化学文摘社编号:
分子量:
506.46
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
223-501-8
MDL number:
Beilstein/REAXYS Number:
599390
Assay:
≥98%
产品名称
链黑霉素 来源于柔毛链霉菌, ≥98%
Quality Segment
assay
≥98%
antibiotic activity spectrum
viruses
mode of action
DNA synthesis | interferes
storage temp.
2-8°C
SMILES string
COc1ccc(c(O)c1OC)-c2c(C)c(nc(c2N)-c3ccc4C(=O)C(OC)=C(N)C(=O)c4n3)C(O)=O
InChI
1S/C25H22N4O8/c1-9-14(10-6-8-13(35-2)23(36-3)20(10)30)15(26)19(29-17(9)25(33)34)12-7-5-11-18(28-12)22(32)16(27)24(37-4)21(11)31/h5-8,30H,26-27H2,1-4H3,(H,33,34)
InChI key
PVYJZLYGTZKPJE-UHFFFAOYSA-N
Biochem/physiol Actions
Streptonigrin (SN) is an aminoquinone antitumour antibiotic. Its antineoplastic activity requires reductive activation by Xanthine-converting enzymes. It induces apoptosis by a mechanism involving NF-κB. DNA cleavage reaction and chromosome damage by SN are influenced by the nature of the metal ion present and dependent on the production of free radicals. Its antibiotic activity is iron-activated.
警示词
Danger
危险代码
Hazard Classifications
Acute Tox. 1 Oral
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
怎么回事？
WGK 3
闪点 (F)
Not applicable
闪点 (°C)
Not applicable
PPE（个人防护设备）
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges