重组
expressed in E. coli
质量水平
方案
≥90% (SDS-PAGE)
表单
lyophilized powder
UniProt登记号
运输
dry ice
储存温度
−20°C
基因信息
human ... SNCA(6622)
一般描述
α-Synuclein定位于人染色体4q22.1。它是一种固有的无序蛋白，具有N端不完美重复序列（KTKEGV），对聚集至关重要的中央NAC和酸性富集的柔性C端区域。α-Synuclein存在于路易体（LBs）和路易神经突（LNs）中。
应用
α在活性氧（ROS）测量，免疫组织化学和成像研究之前，已将人-Synuclein A53T用于治疗中脑神经元并刺激小胶质细胞。
生化/生理作用
α-Synuclein（α-Syn）与Toll样受体2（TLR2）相互作用，介导白细胞介素-1β（IL-1β）合成。
α-突触核蛋白基因中的点突变A53T（Ala53-Thr）与家族性帕金森氏′病有关。
α-突触核蛋白基因中的点突变A53T（Ala53-Thr）与家族性帕金森氏′病有关。 表达A53T人α-突触核蛋白但不表达野生型或A30P变体的小鼠会发展为成年发作的神经退行性疾病，并伴有进行性运动 功能障碍，导致死亡。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
此项目有
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Nathan Meyer et al.
ACS central science, 8(4), 441-448 (2022-05-05)
The detection to α-synuclein (αS) assemblies as a biomarker of synucleinopathies is an important challenge for further development of an early diagnosis tool. Here, we present proof of concept real-time fast amyloid seeding and translocation (RT-FAST) based on a nanopipette
Yan Zhou et al.
Molecular neurodegeneration, 11, 28-28 (2016-04-17)
α-Synuclein (α-Syn), a pathological hallmark of Parkinson's disease (PD), has been recognized to induce the production of interleukin-1β in a process that depends, at least in vitro, on nod-like receptor protein 3 (NLRP3) inflammasome in monocytes. However, the role of
A short motif in the N-terminal region of α-synuclein is critical for both aggregation and function.
Ciaran P A Doherty et al.
Nature structural & molecular biology, 27(3), 249-259 (2020-03-12)
Aggregation of human α-synuclein (αSyn) is linked to Parkinson's disease (PD) pathology. The central region of the αSyn sequence contains the non-amyloid β-component (NAC) crucial for aggregation. However, how NAC flanking regions modulate αSyn aggregation remains unclear. Using bioinformatics, mutation
Laura Rueda-Gensini et al.
Frontiers in pharmacology, 13, 905347-905347 (2022-07-16)
Plant-derived products have gained considerable attention as inflammation modulators given the wide variety of anti-inflammatory phytochemicals reported to be present in plants and their limited side effects in vivo during prolonged exposure periods. Non-centrifugal cane sugar (NCS) has been identified
Muhammad Abdul Alim et al.
Journal of Alzheimer's disease : JAD, 6(4), 435-442 (2004-09-04)
Alpha-synuclein is a major constituent of pathological intracellular inclusion bodies, a common feature of several neurodegenerative diseases. Two missense mutations in the alpha-synuclein gene have been identified in confirmed autosomal-dominant familial Parkinson's disease, which segregate with the illness. However, the
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