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Merck
CN

S1141

Sigma-Aldrich

精胺 四盐酸盐

BioReagent, Molecular Biology

别名:

N,N′-双(3-氨丙基)-1,4-丁二胺 四盐酸盐

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关于此项目

经验公式（希尔记法）:
C10H26N4 · 4HCl
化学文摘社编号:
306-67-2
分子量:
348.18
Beilstein:
3911771
EC 号:
206-189-8
MDL编号:
MFCD00012914
UNSPSC代码:
12352116
PubChem化学物质编号:
24899462
NACRES:
NA.52

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等级

Molecular Biology

质量水平

300

产品线

BioReagent

表单

solid

mp

310-311 °C (dec.) (lit.)

溶解性

H2O: soluble 100 mg/mL, clear, colorless to light yellow

异质活性

DNase, RNase, protease, NICKase, none detected

储存温度

room temp

SMILES字符串

Cl.Cl.Cl.Cl.NCCCNCCCCNCCCN

InChI

1S/C10H26N4.4ClH/c11-5-3-9-13-7-1-2-8-14-10-4-6-12;;;;/h13-14H,1-12H2;4*1H

InChI key

XLDKUDAXZWHPFH-UHFFFAOYSA-N

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一般描述

精胺是一种多胺，参与细胞代谢和 DNA 稳定。在分子生物学中，它可用于纯化 DNA 的缓冲液。

应用

用于从低盐缓冲液中沉淀 DNA。

生化/生理作用

多胺位点混合型 NMDA 激动-拮抗剂。在细胞增殖和分化中发挥作用；抑制神经元一氧化氮合成酶 (nNOS)。
多胺位点混合型 NMDA 激动-拮抗剂。在高浓度 (1mM) 下观察到神经保护作用，而在低浓度下则观察到神经毒性。它在番木鳖碱-不敏感性甘氨酸位点能够增强激动剂效应。在细胞增殖和分化中发挥作用；抑制神经元一氧化氮合成酶 (nNOS)。

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H315,H319

危险分类

Eye Irrit. 2 - Skin Irrit. 2

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCM7828
BCCL7411
BCCK7695
BCCH9915
BCCG9744

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L L Vindeløv et al.
Cancer research, 40(11), 4295-4300 (1980-11-01)
Flow-cytometric DNA analysis yields information on ploidy and proliferative characteristics of a cell population. The analysis was implemented on small-cell anaplastic carcinoma of the lung using a rapid detergent technique for the preparation of fine-needle aspirates for DNA determination and
D M Hougaard et al.
The Biochemical journal, 238(1), 43-47 (1986-08-15)
Two recently developed fluorescence cytochemical methods, specific for spermidine and spermine, were used to localize polyamines in the endocrine pancreas. The polyamines were restricted to the insulin-producing beta-cells and were mainly associated with the secretory granules. Chemical polyamine determinations carried
D C Allison et al.
Annals of surgery, 214(6), 648-656 (1991-12-01)
The DNA content of 47 adenocarcinomas arising in the head of the pancreas from patients who had undergone successful pancreatoduodenectomy was measured. The DNA measurements of each tumor were made without knowledge of the clinical course by absorption cytometry performed
Aracely A Lutes et al.
Proceedings of the National Academy of Sciences of the United States of America, 108(24), 9910-9915 (2011-05-06)
Speciation in animals commonly involves an extrinsic barrier to genetic exchange followed by the accumulation of sufficient genetic variation to impede subsequent productive interbreeding. All-female species of whiptail lizards, which originated by interspecific hybridization between sexual progenitors, are an exception
Davis, L., et al.
Basic Methods in Molecular Biology, 120-120 (1986)
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实验方案

Spermine Tetrahydrochloride for Molecular Biology

This product is suitable for DNA precipitation from low salt aqueous buffers. It has been tested for the absence of proteases and nucleases.

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